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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
TLDR
By integrating RNA interference–mediated depletion of Oct4 and Nanog with microarray expression profiling, it is demonstrated that these factors can activate or suppress transcription, and it is shown that common core downstream targets are important to keep ES cells from differentiating. Expand
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
TLDR
A broad, drug-like phase II metabolic response of the host to metabolites generated by the microbiome was observed, suggesting that the gut microflora has a direct impact on the drug metabolism capacity of theHost. Expand
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase.
TLDR
G0S2 functions to attenuate ATGL action both in vitro and in vivo and by this mechanism regulates TAG hydrolysis. Expand
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
TLDR
LGK974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo, including murine and rat mechanistic breast cancer models driven by MMTV–Wnt1 and a human head and neck squamous cell carcinoma model (HN30). Expand
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
TLDR
An essential role for CAR is demonstrated in regulating both liver homeostasis and tumorigenesis in response to xenobiotic stresses, and a specific molecular mechanism linking chronic environmental stress and tumor formation is identified. Expand
Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole
TLDR
It is concluded that ESX-1 plays an essential role in M. marinum escape from the Mycobacterium-containing vacuole (MCV) and cell-to-cell spread, and results suggest that ESAT-6 secreted by M.Marinum ESx-1 could play a direct role in producing pores in MCV membranes, facilitating M. Marinum Escape from the Vacuole. Expand
Clinical, Pathological, and Molecular Variables Predictive of Malignant Peripheral Nerve Sheath Tumor Outcome
TLDR
MPSNT is a markedly metastatic and aggressive poor prognosis tumor and multiple clinical, pathologic, and molecular markers identified in this study, coupled with findings from previous series, should be considered for an improved MPNST staging system useful for prognostic assessment and management decisions. Expand
Protein-Protein Interactions Mediate Mitochondrial Cholesterol Transport and Steroid Biosynthesis*
TLDR
The results suggest that the initiation of cAMP-induced protein-protein interactions results in the formation of a multivalent scaffold in the outer mitochondrial membrane that mediates the effect of hormones on mitochondrial cholesterol transport and steroidogenesis. Expand
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein.
TLDR
This work shows that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation and suggests that YAP may integrate spatial, mechanical, and metabolic signals to control cellular proliferation and survival. Expand
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis.
TLDR
The results suggest that the highly ordered alterations of 5 hmC in the mouse genome are potentially crucial for the differentiation of spermatogenic cells. Expand
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