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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. Conversely, loss of Bmi1… Expand
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth
Glioblastomas (GBMs) are highly vascular and lethal brain tumors that display cellular hierarchies containing self-renewing tumorigenic glioma stem cells (GSCs). Because GSCs often reside in… Expand
Optic pathway gliomas: a review.
Optic pathway gliomas represent approximately 3-5% of childhood intracranial tumors. They usually occur in children during the first decade of life and are seen in 11-30% of patients with… Expand
Spinal extradural arachnoid cysts: clinical, radiological, and surgical features.
Extradural arachnoid cysts in the spine are rare and are seldom a cause of spinal cord compression. They are thought to arise from congenital defects in the dura mater, and they almost always… Expand
Primary Intraosseous Skull Base Cavernous Hemangioma: Case Report.
- J. Liu, P. C. Burger, H. Harnsberger, W. Couldwell
- Skull base : official journal of North American…
- 1 November 2003
Primary intraosseous cavernous hemangiomas (PICHs) of the skull base are extremely rare tumors. These lesions are most common in the frontal and parietal bones of the calvarium. The authors describe… Expand
Cavernous malformations of the optic pathway and hypothalamus: analysis of 65 cases in the literature.
OBJECT Cavernous malformations (CMs) of the optic pathway and hypothalamus (OPH) are extremely rare. Patients with these lesions typically present with chiasmal apoplexy, characterized by sudden… Expand
Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors.
OBJECT The optimal management of glomus jugulare tumors remains controversial. Available treatments were once associated with poor outcomes and significant complication rates. Advances in skull base… Expand
Update on the diagnosis, pathogenesis, and treatment strategies for central neurocytoma
Central neurocytomas are rare benign tumors of the central nervous system that are typically located in the lateral ventricles. Since they were first reported in the early 1980s, many advancements… Expand
Variations on the Standard Transsphenoidal Approach to the Sellar Region, with Emphasis on the Extended Approaches and Parasellar Approaches: Surgical Experience in 105 Cases
- W. Couldwell, M. Weiss, C. Rabb, J. Liu, R. Apfelbaum, T. Fukushima
- 1 September 2004
OBJECTIVE:The traditional boundaries of the transsphenoidal approach may be expanded to include the region from the cribriform plate of the anterior cranial base to the inferior clivus in the… Expand
Historical perspectives on the diagnosis and treatment of trigeminal neuralgia.
Since the earliest recorded history of medicine, physicians have been challenged by the difficulty in relieving the great pain experienced by individuals suffering from trigeminal neuralgia (TN). The… Expand