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Molecular cloning and functional expression of a mu opioid receptor from rat brain
Opioid drugs act on specific receptors to modulate a wide range of physiological functions. There are at least three types of opioid receptors, mu, delta, and kappa. Using a cDNA probe for a mouseExpand
`Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation
Msx2-deficient mice exhibit progressive hair loss, starting at P14 and followed by successive cycles of wavelike regrowth and loss. During the hair cycle, Msx2 deficiency shortens anagen phase, butExpand
Non-high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart disease.
To determine if non-high-density lipoprotein (HDL) cholesterol is a more useful predictor of coronary heart disease (CHD) risk than low-density lipoprotein (LDL) cholesterol and if very-low-densityExpand
The Endotoxin Delivery Protein HMGB1 Mediates Caspase‐11‐Dependent Lethality in Sepsis
Graphical Abstract Figure. No caption available. SUMMARY Caspase‐11, a cytosolic endotoxin (lipopolysaccharide: LPS) receptor, mediates pyroptosis, a lytic form of cell death. Caspase‐11‐dependentExpand
An Epidemiologic Study of Posttraumatic Stress Disorder in Flood Victims in Hunan China
  • A. Liu, H. Tan, +7 authors S. Wen
  • Medicine
  • Canadian journal of psychiatry. Revue canadienne…
  • 1 May 2006
Objective: To estimate the occurrence and to assess the determinants of posttraumatic stress disorder (PTSD) in flood victims. Method: We carried out a retrospective study to examine the occurrenceExpand
Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity
Background— Carnitine palmitoyltransferase-1 (CPT1) is a rate-limiting step of mitochondrial &bgr;-oxidation by controlling the mitochondrial uptake of long-chain acyl-CoAs. The muscle isoform,Expand
Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1[S]
Adipose tissue macrophage (ATM) plays a central role in obesity-associated inflammation and insulin resistance. Quercetin, a dietary flavonoid, possesses anti-inflammation and anti-insulin resistanceExpand
Joint distribution of non-HDL and LDL cholesterol and coronary heart disease risk prediction among individuals with and without diabetes.
OBJECTIVE To assess coronary heart disease (CHD) risk within levels of the joint distribution of non-HDL and LDL cholesterol among individuals with and without diabetes. RESEARCH DESIGN AND METHODSExpand
Dipeptidyl Peptidase 4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension Through a Glucagon–Like Peptide 1–Dependent Mechanism
Sitagliptin, a selective dipeptidyl peptidase 4 inhibitor, inhibits the inactivation and degradation of glucagon like peptide 1 (GLP-1), which is used for the treatment of type 2 diabetes mellitus.Expand
Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like Properties
Hypoxia is an important environmental change in many cancers. Hypoxic niches can be occupied by cancer stem/progenitor-like cells that are associated with tumor progression and resistance toExpand