• Publications
  • Influence
The molecular basis of CaMKII function in synaptic and behavioural memory
Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary model by which to study the cellular and molecular basis of memory. Calcium/calmodulin-dependent protein kinaseExpand
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A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
According to the Hebb rule, the change in the strength of a synapse depends only on the local interaction of presynaptic and postsynaptic events. Studies at many types of synapses indicate that theExpand
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Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent.
Chemically induced long-term potentiation (cLTP) could potentially work by directly stimulating the biochemical machinery that underlies synaptic plasticity, bypassing the need for synapticExpand
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The CaM kinase II hypothesis for the storage of synaptic memory
  • J. Lisman
  • Biology, Medicine
  • Trends in Neurosciences
  • 1994
Much has been learned about the activity-dependent synaptic modifications (long-term potentiation and long-term depression) that are thought to underlie memory storage, but the mechanism by whichExpand
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Gamma oscillations correlate with working memory load in humans.
Functional imaging of human cortex implicates a diverse network of brain regions supporting working memory - the capacity to hold and manipulate information for short periods of time. Although we areExpand
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Persistent Accumulation of Calcium/Calmodulin-Dependent Protein Kinase II in Dendritic Spines after Induction of NMDA Receptor-Dependent Chemical Long-Term Potentiation
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a leading candidate for a synaptic memory molecule because it is persistently activated after long-term potentiation (LTP) induction andExpand
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Role of the CaMKII/NMDA Receptor Complex in the Maintenance of Synaptic Strength
During long-term potentiation (LTP), synapses undergo stable changes in synaptic strength. The molecular memory processes that maintain strength have not been identified. One hypothesis is that theExpand
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NMDA Receptor-Mediated Subthreshold Ca2+ Signals in Spines of Hippocampal Neurons
We have used rapid confocal microscopy to investigate the mechanism of Ca2+ signals in individual dendritic spines of hippocampal CA1 pyramidal cells. The experiments focused on the signals thatExpand
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Autonomous CaMKII Can Promote either Long-Term Potentiation or Long-Term Depression, Depending on the State of T305/T306 Phosphorylation
Ca2+/calmodulin-dependent kinase II (CaMKII) is a key mediator of long-term potentiation (LTP). Whereas acute intracellular injection of catalytically active CaMKII fragments saturates LTP (Lledo etExpand
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Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity
Long-term potentiation and long-term depression require postsynaptic depolarization, which many current models attribute to backpropagating action potentials. New experimental work suggests, however,Expand
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