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The c-Fes family of protein-tyrosine kinases.
This review highlights the unique aspects of Fes structure, regulation, and function that set it apart from other tyrosine kinase families. Expand
Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain
- Katherine E. Stockstill, T. Doyle, +15 authors D. Salvemini
- The Journal of experimental medicine
- 7 May 2018
It is reported that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S 1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P. Expand
Oligomerization of the Fes Tyrosine Kinase
- R. Read, J. Lionberger, T. Smithgall
- Biology, Medicine
- The Journal of Biological Chemistry
- 18 July 1997
The c-fes proto-oncogene encodes a non-receptor tyrosine kinase (Fes) that has been implicated in cytokine receptor signal transduction and myeloid differentiation and suggest that oligomerization may be a prerequisite for trans-autophosphorylation and activation of Fes. Expand
Augmented and standard Berlin–Frankfurt–Münster chemotherapy for treatment of adult acute lymphoblastic leukemia
The augmented Berlin–Frankfurt–Münster (aBFM) regimen has demonstrated improved outcomes in children with acute lymphomblastic leukemia (ALL), but efficacy in adults is unknown. In this retrospective… Expand
Heterogeneity of clonal expansion and maturation-linked mutation acquisition in hematopoietic progenitors in human acute myeloid leukemia
Heterogeneity among progenitors in human AML may have prognostic and therapeutic implications after a co-culture method integrating hypoxia, aryl hydrocarbon receptor inhibition and micro-environmental support via human endothelial cells to isolate these cells. Expand
Cytoskeleton‐bound polysomes in plants. III. Polysome‐cytoskeleton‐membrane interactions in corn endosperm.
It is suggested that many of the polysomes in corn endosperm are associated via their ribosomes, but not mRNA or nascent polypeptides with the actin component of the cytoskeleton and only indirectly with membranes. Expand
The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl.
Results show that Fes and Bcr-Abl interact in myeloid cells, leading to Fes activation and suppression of Bcr -Abl-induced conversion to cytokine independence. Expand
Tumor lysis syndrome and metastatic melanoma
The case of a patient with newly diagnosed metastatic melanoma that developed TLS two days after initiation of corticosteroids is described. Expand
Acute Myeloid Leukemia Induction with Cladribine: Effects of Age and Leukemia Risk
Cladribine combined with cytarabine and idarubicin is an effective induction regimen for AML with high rates of CR, even in patients 60 and older, and NCCN leukemia risk is a better predictor of survival compared to age. Expand
Frequency of allogeneic hematopoietic cell transplantation among patients with high- or intermediate-risk acute myeloid leukemia in first complete remission.
- R. Mawad, T. Gooley, +14 authors J. Pagel
- Journal of clinical oncology : official journal…
- 1 November 2013
HCT can be performed in CR1 in the majority of patients with acute myeloid leukemia for whom it is currently recommended, and the main barriers to HCT were early relapse and poor performance status, highlighting the need for improved therapies for patients with AML of all ages. Expand