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Receptors: Models for Binding, Trafficking, and Signaling
Introduction. 1: Cell Surface Receptor/Ligand Binding Fundamentals. 2: Receptor/Ligand Trafficking. 3: Physical Aspects of Receptor/Ligand Binding and Trafficking Processes. 4: Signal Transduction.Expand
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Receptors: Models for Binding
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Mathematical modeling of helper T lymphocyte/antigen-presenting cell interactions: analysis of methods for modifying antigen processing and presentation.
Helper T lymphocytes (Th cells) are activated by contact with antigen-presenting cells (APCs) that have processed and presented the appropriate MHC-peptide complexes. Two experimental methods forExpand
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A Spatial Focusing Model for G Protein Signals
Regulators of G protein signaling (RGS) are GTPase-accelerating proteins (GAPs), which can inhibit heterotrimeric G protein pathways. In this study, we provide experimental and theoretical evidenceExpand
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Toward a multiscale model of antigen presentation in immunity
Summary:  A functioning immune system and the process of antigen presentation in particular encompass events that occur at multiple length and time scales. Despite a wealth of information in theExpand
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Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy.
Signaling through G-protein coupled receptors is one of the most prevalent and important methods of transmitting information to the inside of cells. Many mathematical models have been proposed toExpand
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CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, bothExpand
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Receptor Up-regulation, Internalization, and Interconverting Receptor States
High resolution kinetic data of the binding of fluorescent peptide to the N-formyl peptide receptor of neutrophils at 37°C has allowed for the development of a ligand binding model that predictsExpand
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Characterizing the Dynamics of CD4+ T Cell Priming within a Lymph Node
Generating adaptive immunity postinfection or immunization requires physical interaction within a lymph node T zone between Ag-bearing dendritic cells (DCs) and rare cognate T cells. Many fundamentalExpand
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Modeling of G-protein-coupled Receptor Signaling Pathways*
  • J. Linderman
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 27 February 2009
G-protein-coupled receptors (GPCRs)2 are the largest family of cell membrane receptors. An estimated 50% of current pharmaceuticals target GPCRs (1), suggesting that further increases in ourExpand
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