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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
TLDR
Increase in PGC-1alpha levels dramatically protects neural cells in culture from oxidative-stressor-mediated death, providing a potential target for the therapeutic manipulation of these important endogenous toxins. Expand
Metabolic control through the PGC-1 family of transcription coactivators.
TLDR
This work has shown that the PGC-1 coactivators play a critical role in the maintenance of glucose, lipid, and energy homeostasis and are likely involved in the pathogenic conditions such as obesity, diabetes, neurodegeneration, and cardiomyopathy. Expand
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
TLDR
Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression. Expand
PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
TLDR
The high levels of P GC-1α in dark and exercising muscles can explain their resistance to atrophy, and the rapid fall in PGC-1 α during atrophy should enhance the FoxO-dependent loss of muscle mass. Expand
Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP
TLDR
It is shown here that high-fat feeding, which induces hyperlipidemia and atherogenesis, stimulates the expression of both PGC-1beta and SREBP1c and 1a in liver, suggesting a mechanism through which dietary saturated fats can stimulate hyperlipIDemia and Atherogenesis. Expand
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.
TLDR
The data suggest an autofeedback loop whereby the calcium-signaling pathway may result in a stable induction of PGC-1alpha, contributing to the relatively stable nature of muscle fiber-type determination. Expand
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.
TLDR
The cloning of a novel bona fide homologue of PGC-1 was described, and a conserved amino acid motif is identified that serves as a docking site for host cell factor, a cellular protein implicated in cell cycle regulation and viral infection. Expand
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
TLDR
P160 myb binding protein (p160MBP) is a powerful negative regulator of PGC-1alpha function and provide a molecular mechanism for the activation of P GC-1 alpha by p38 MAPK. Expand
An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
TLDR
It is shown that the PGC-1α promoter is regulated by both CaMKIV and CnA activity, implying a unified pathway, integrating key regulators of calcium signaling with the transcriptional switch P GC-1 α, contributing to the relatively stable nature of muscle fiber-type determination. Expand
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.
TLDR
Using genetic knockout mice, it is shown that, while PGC-1alpha KO mice appear to retain normal mitochondrial volume in both muscle beds, expression of genes of oxidative phosphorylation is markedly blunted, indicating that P GC-1 alpha is vital for the heart to meet increased demands for ATP and work in response to physiological stimuli. Expand
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