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Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans
TLDR
Although the COmbined FRActional DIagonal Chromatography technology was used to determine the N-terminal acetylation status of 742 human and yeast protein N termini, it was revealed that NatA from humans and yeast have identical or nearly identical specificities.
Genomic Insights into Methanotrophy: The Complete Genome Sequence of Methylococcus capsulatus (Bath)
TLDR
Evidence is gained for greater metabolic flexibility than was previously known, and for genetic components that may have biotechnological potential, in M. capsulatus, including an ability to grow on sugars, oxidize chemolithotrophic hydrogen and sulfur, and live under reduced oxygen tension, all of which have implications for methanotroph ecology.
Gene Expression Profiling–Based Identification of Molecular Subtypes in Stage IV Melanomas with Different Clinical Outcome
TLDR
The data reveal a biologically based taxonomy of malignant melanomas with prognostic effect and support an influence of the antitumoral immune response on outcome.
Structural and functional specificities of PDGF‐C and PDGF‐D, the novel members of the platelet‐derived growth factors family
TLDR
The published data on the PDGF family is reviewed, covering structural (gene and protein) similarities and differences among all four family members, with special focus on PDGF‐C andPDGF‐D expression and functions.
Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer.
TLDR
The observation that the majority of patients with TP53 mutations affecting or disrupting the L2/L3 domains with LOH in addition obtained a partial response or stabilization of disease during chemotherapy suggests redundant mechanisms to compensate for loss of p53 function.
Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.
TLDR
The human homologue of Nat1p, NATH (NAT human), is described as the partner of the hARD1 (human ARD1) protein, and new aspects of the NATH and hard1 proteins relative to their yeast homologues are presented.
The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.
TLDR
In vitro analyses reveals that SNP309G enhances but SNP285C strongly reduces Sp1 promoter binding, and a second MDM2 promoter polymorphism, SNP285G > C, residing on the SNP 309G allele is reported.
Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha.
TLDR
It is demonstrated that the level of human ARD1 (hARD1) protein is not decreased in hypoxia and hARD1 specifically binds HIF-1 alpha, suggesting a putative, still unclear, connection between these proteins.
Proteome-derived Peptide Libraries Allow Detailed Analysis of the Substrate Specificities of Nα-acetyltransferases and Point to hNaa10p as the Post-translational Actin Nα-acetyltransferase*
TLDR
A method that implies the use of natural, proteome-derived modified peptide libraries, which, when used in combination with two strong cation exchange separation steps, allows for the delineation of the in vitro specificity profiles of NATs.
Cloning and characterization of hNAT5/hSAN: An evolutionarily conserved component of the NatA protein N-α-acetyltransferase complex
TLDR
The first description of the human homologue of Nat5p/San, hNAT5, the third component of thehuman NatA N-α-acetyltransferase complex is presented.
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