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Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
One of many protein–protein interactions modulated upon DNA damage is that of the single-stranded DNA-binding protein, replication protein A (RPA), with the p53 tumor suppressor. Here we report theExpand
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Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
USP7/HAUSP is a key regulator of p53 and Mdm2 and is targeted by the Epstein-Barr nuclear antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV). We have determined the crystal structure of the p53Expand
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Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?
The BRCA1 tumor suppressor gene encodes an 1863 amino acid gene product that is implicated in many cellular pathways including transcription, cell-cycle checkpoint control, apoptosis and DNA repair.Expand
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An NMR approach to structural proteomics
The influx of genomic sequence information has led to the concept of structural proteomics, the determination of protein structures on a genome-wide scale. Here we describe an approach to structuralExpand
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An NMR approach to structural proteomics.
Adelinda Yee*, Xiaoqing Chang*, Antonio Pineda-Lucena*, Bin Wu*, Anthony Semesi*, Brian Le*, Theresa Ramelot†, Gregory M. Lee‡, Sudeepa Bhattacharyya§, Pablo Gutierrez¶, Aleksej Denisov¶, Chang-HunExpand
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Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.
IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins. It has been implicated in transcriptional regulation by modulating protein-protein interactions with p53 tumorExpand
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DNA and RNA Quadruplex-Binding Proteins
Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i-Motifs, minor grooveExpand
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NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli
Here we describe the solution structure of YjbJ (gil418541) as part of a structural proteomics project on the feasibility of the high-throughput generation of samples from Escherichia coli forExpand
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Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.
Interferon (IFN)-inducible HIN-200 proteins play an important role in transcriptional regulation linked to cell cycle control, inflammation, autoimmunity and differentiation. IFI16 has beenExpand
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Preferential binding of p53 tumor suppressor to p21 promoter sites that contain inverted repeats capable of forming cruciform structure.
p53 Is one of the most critical proteins involved in protecting organisms from malignancies and its gene is frequently mutated in these diseases. p53 Functions as a transcription factor and its roleExpand
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