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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
Mutationally activated kinases define a clinically validated class of targets for cancer drug therapy. However, the efficacy of kinase inhibitors in patients whose tumours harbour such alleles is… Expand
Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH
Ageing is a result of gradual and overall functional deteriorations across the body; however, it is unknown whether an individual tissue primarily works to mediate the ageing progress and control… Expand
IKKβ/NF-κB Disrupts Adult Hypothalamic Neural Stem Cells to Mediate Neurodegenerative Mechanism of Dietary Obesity and Pre-Diabetes
Adult neural stem cells (NSCs) are known to exist in a few regions of the brain; however, the entity and physiological/disease relevance of adult hypothalamic NSCs (htNSCs) remain unclear. This work… Expand
Neuropeptide Exocytosis Involving Synaptotagmin-4 and Oxytocin in Hypothalamic Programming of Body Weight and Energy Balance
Hypothalamic neuropeptides play essential roles in regulating energy and body weight balance. Energy imbalance and obesity have been linked to hypothalamic signaling defects in regulating… Expand
Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response
The brain, in particular the hypothalamus, plays a role in regulating glucose homeostasis; however, it remains unclear whether this organ is causally and etiologically involved in the development of… Expand
Skeletal myogenic potential of mouse skin-derived precursors.
- Zhifang Qiu, Chenglin Miao, +5 authors En-kui Duan
- Biology, Medicine
- Stem cells and development
- 25 February 2010
Cell transplantation-based therapy could be an effective way for the treatment of many diseases. Among numerous somatic stem cells isolated and purified, skin-derived precursors (SKPs) are abundant… Expand
Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation.
Dickkopf-1 (Dkk1) is one of the secreted antagonists in the canonical Wnt signaling pathway. It plays important roles in diverse developmental processes. However, the role of Dkk1 in trophoblast cell… Expand
Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness
The enrichment and identification of human epidermal stem cells (EpSCs) are of paramount importance for both basic research and clinical application. Although several approaches for the enrichment of… Expand
High level of FOXC1 expression is associated with poor prognosis in pancreatic ductal adenocarcinoma
Accumulating evidence for overexpression of FOXC1 in various types of human cancer suggests that it plays a key role in tumor biology. However, little is known about the function of FOXC1 in… Expand
Effects of Wnt3a on proliferation and differentiation of human epidermal stem cells.
- L. Jia, J. Zhou, S. Peng, J. Li, Yu-jing Cao, E. Duan
- Biology, Medicine
- Biochemical and biophysical research…
- 11 April 2008
Epidermal stem cells maintain development and homeostasis of mammalian epidermis throughout life. However, the molecular mechanisms involved in the proliferation and differentiation of epidermal stem… Expand