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Redefining the invertebrate RNA virosphere
A view of the RNA virosphere is presented that is more phylogenetically and genomically diverse than that depicted in current classification schemes and provide a more solid foundation for studies in virus ecology and evolution. Expand
The diploid genome sequence of an Asian individual
Genotyping analysis showed that SNP identification had high accuracy and consistency, indicating the high sequence quality of this assembly, and the potential usefulness of next-generation sequencing technologies for personal genomics. Expand
Population analysis of large copy number variants and hotspots of human genetic disease.
- A. Itsara, G. Cooper, +11 authors E. Eichler
- Biology, Medicine
- American journal of human genetics
- 13 February 2009
Although large CNVs commonly exist in normal individuals, this study suggests that size alone can not be used as a predictor of pathogenicity, such variation is generally deleterious and both gene density and size are strongly anticorrelated with allele frequency. Expand
Phylogeny-Based Evolutionary, Demographical, and Geographical Dissection of North American Type 2 Porcine Reproductive and Respiratory Syndrome Viruses
This study represents the most extensive phylogenetic analyses of type 2 PRRSV to date, providing a basis for future genotyping studies and dissecting the epidemiological and evolutionary behaviors of type 1 PR RSV from phylogenetic perspectives. Expand
Whole-genome sequencing reveals untapped genetic potential in Africa’s indigenous cereal crop sorghum
These assembled genomes enable the leveraging of existing cereal functional genomics data against the novel diversity available in Sorghum, providing an unmatched resource for the genetic improvement of sorghum and other grass species. Expand
Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity.
The first comprehensive genomic survey of the immune gene repertoire of the Amphioxus Branchiostoma floridae suggests that the amphioxus, a species without vertebrate-type adaptive immunity, holds extraordinary innate complexity and diversity. Expand
Natural Malaria Infection in Anopheles gambiae Is Regulated by a Single Genomic Control Region
We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite,… Expand
Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1.
Results indicate that the extracellular domain of BRI1 perceives brassinosteroids, which suggest a general signaling mechanism for the LRR receptor kinases of plants, and should allow the discovery of ligands for the largest group of plant receptor Kinases. Expand
Early millet use in northern China
- Xiaoyan Yang, Z. Wan, +10 authors Q. Ge
- Medicine, Geography
- Proceedings of the National Academy of Sciences
- 21 February 2012
Ancient starch grain assemblages recovered from cultural deposits are presented, including carbonized residues adhering to an early pottery sherd as well as grinding stone tools excavated from the sites of Nanzhuangtou and Donghulin, extending the record of millet use in China by nearly 1,000 y and the record in the region by at least two millennia. Expand
Gene replacements and insertions in rice by intron targeting using CRISPR–Cas9
Efficient intron-mediated site-specific gene replacement and insertion approaches that generate mutations using the non-homologous end joining (NHEJ) pathway using the clustered regularly interspaced short palindromic repeats (CRISPR)– CRISPR-associated protein 9 (Cas9) system are reported. Expand