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Connexins regulate calcium signaling by controlling ATP release.
Forced expression of gap junction proteins, connexins, enables gap junction-deficient cell lines to propagate intercellular calcium waves. Here, we show that ATP secretion from the poorly coupledExpand
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IL-27 regulates IL-12 responsiveness of naïve CD4+ T cells through Stat1-dependent and -independent mechanisms
IL-27, a novel heterodimeric cytokine produced by antigen-presenting cells, signals through the T cell cytokine receptor (TCCR)/WSX-1 expressed on naïve CD4+ T cells and natural killer cells.Expand
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Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
Understanding cellular response to environmental stress has broad implications for human disease. AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and -consumingExpand
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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
Originally published as 402, 304–309; 1999Bone remodelling and bone loss are controlled by a balance between the tumour necrosis factor family molecule osteoprotegerin ligand (OPGL) and its decoyExpand
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RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.
  • J. Li, I. Sarosi, +20 authors W. Boyle
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 February 2000
We have generated RANK (receptor activator of NF-kappaB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during boneExpand
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Induction of leptin resistance through direct interaction of C-reactive protein with leptin
The mechanisms underlying leptin resistance are still being defined. We report here the presence in human blood of several serum leptin-interacting proteins (SLIPs), isolated by leptin-affinityExpand
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Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.
The oncogene p3k, coding for a constitutively active form of phosphatidylinositol 3-kinase (PI 3-kinase), strongly activates myogenic differentiation. Inhibition of endogenous PI 3-kinase activityExpand
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Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice.
  • J. Pak, F. Huang, +5 authors K. Huang
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 10 October 2000
Neurogranin/RC3 is a neural-specific Ca(2+)-sensitive calmodulin (CaM)-binding protein whose CaM-binding affinity is modulated by phosphorylation and oxidation. Here we show that deletion of the NgExpand
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AMP-activated protein kinase regulates the assembly of epithelial tight junctions
AMP activated protein kinase (AMPK), a sensor of cellular energy status in all eukaryotic cells, is activated by LKB1-dependent phosphorylation. Recent studies indicate that activated LKB1 inducesExpand
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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.
Mutations affecting the activity of the Wnt co-receptors LRP5 and LRP6 that cause alterations in skeletal biology confirmed the involvement of Wnt signaling in bone formation. We evaluated theExpand
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