• Publications
  • Influence
Structure--activity relationships of polymyxin antibiotics.
Tony Velkov,* Philip E. Thompson, Roger L. Nation, and Jian Li* School of Medicine, Deakin University, Pigdons Road, Geelong 3217, Victoria, Australia, Medicinal Chemistry and Drug Action andExpand
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How instructed knowledge modulates the neural systems of reward learning
Recent research in neuroeconomics has demonstrated that the reinforcement learning model of reward learning captures the patterns of both behavioral performance and neural responses during a range ofExpand
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Pharmacology of polymyxins: new insights into an 'old' class of antibiotics.
Increasing antibiotic resistance in Gram-negative bacteria, particularly in Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global medical challenge. No newExpand
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International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious
The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the 1950s and thus did not undergo contemporary drug development procedures. Their clinical use has recentlyExpand
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Assessing the Detoxication Efficiencies of Wastewater Treatment Processes Using a Battery of Bioassays/Biomarkers
  • M. Ma, J. Li, Z. Wang
  • Chemistry, Medicine
  • Archives of environmental contamination and…
  • 30 September 2005
A battery of in vitro bioassays, including a Neutral Red (NR) assay using MCF-7 cells for predicting cytotoxic chemicals, an ethoxy resorufin-O-deethylase (EROD) activity assay using H4IIE cells toExpand
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The differential expression of metabolites in wood-forming tissue in response to abiotic stresses might regulate or decide the cell wall contents and architecture via multiple pathways or networks.Expand
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Efficient segmental isotope labeling of multi-domain proteins using Sortase A
NMR studies of multi-domain protein complexes provide unique insight into their molecular interactions and dynamics in solution. For large proteins domain-selective isotope labeling is desired toExpand
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Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development
Lack of clinically relevant tumor models dramatically hampers development of effective therapies for hepatocellular carcinoma (HCC). Establishment of patient-derived xenograft (PDX) models thatExpand
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Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features
  • L. Chen, J. Li, +8 authors H. Jiang
  • Medicine, Chemistry
  • Bioorganic & Medicinal Chemistry
  • 12 October 2006
Abstract The 3C-like protease (3CLpro) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is one of the most promising targets for discovery of drugs against SARS, because ofExpand
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The antigenic architecture of the hemagglutinin of influenza H5N1 viruses.
Human infection with the highly pathogenic avian influenza A virus H5N1 is associated with a high mortality and morbidity. H5N1 continues to transmit from poultry to the human population, raisingExpand
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