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Androgen receptor: structure, role in prostate cancer and drug discovery
TLDR
An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided are provided. Expand
Concepts in Immunology and Diagnosis of Hydatid Disease
TLDR
This review discusses new concepts and approaches in the immunology and diagnosis of echinococcosis, but comparative reference has also been made to AE infection and to earlier pivotal studies of both diseases. Expand
Arsenic and Fluoride Exposure in Drinking Water: Children’s IQ and Growth in Shanyin County, Shanxi Province, China
TLDR
Children’s intelligence and growth can be affected by high concentrations of As or fluoride, and a study of 720 children between 8 and 12 years of age in rural villages in Shanyin county, Shanxi province, China indicates that arsenic exposure can affect children's intelligence and grow. Expand
Dynactin Function in Mitotic Spindle Positioning
TLDR
Dynactin is a multisubunit protein complex necessary for dynein function and interactions among the subunits support a molecular model that resembles the current model for brain dynactin in many respects; however, three subunits at the pointed end of brain dyn actin appear to be absent from yeast. Expand
NudEL targets dynein to microtubule ends through LIS1
TLDR
This work identifies a NUDEL homologue in budding yeast and proposes a model in which Ndl1 binds transiently to the plus end to promote targeting of LIS1, which cooperatively recruits dynein. Expand
Interplant Communication of Tomato Plants through Underground Common Mycorrhizal Networks
TLDR
This finding indicates that CMNs may function as a plant-plant underground communication conduit whereby disease resistance and induced defence signals can be transferred between the healthy and pathogen-infected neighbouring plants, suggesting that plants can ‘eavesdrop’ on defence signals from the Pathogen-challenged neighbours through CMNs to activate defences before being attacked themselves. Expand
Meta‐analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population
TLDR
The findings indicate that the two variants in the FTO gene contribute to obesity and T2D in the Asian populations. Expand
[Human natural infection of Plasmodium knowlesi].
TLDR
A blood film slide taken from a patient previously diagnosed as vivax malaria in Mojiang County, Yunnan Province, showing atypical forms, PCR amplification confirmed that the patient was infected by P. knowlesi. Expand
Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance.
TLDR
Overexpression of LncRNA PVT1 in gastric carcinoma promotes the development of MDR, suggesting an efficacious target for reversing MDR in Gastric cancer therapy. Expand
Resting-State Functional Connectivity Bias of Middle Temporal Gyrus and Caudate with Altered Gray Matter Volume in Major Depression
TLDR
The gray matter reduction of right MTG and bilateral caudate, and disrupted functional connection to widely distributed circuitry in DMN and frontal regions, respectively are revealed, suggesting that the abnormalDMN and reward circuit activity might be biomarkers of depression trait. Expand
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