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IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
Emerging evidence suggests that the T helper 17 (TH17) subset of αβ T cells contributes to the development of allergic asthma. In this study, we found that mice lacking the αvβ8 integrin on dendritic… Expand
Wnt5a regulates Shh and Fgf10 signaling during lung development.
The role of WNT signaling and its interactions with other morphogenetic pathways were investigated during lung development. Previously, we showed that targeted disruption of Wnt5a results in… Expand
Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.
- G. Su, A. Atakilit, +9 authors Dean Sheppard
- American journal of respiratory and critical care…
- 14 December 2012
RATIONALE Sepsis and acute lung injury (ALI) have devastatingly high mortality rates. Both are associated with increased vascular leak, a process regulated by complex molecular mechanisms. … Expand
Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a devastating disorder characterized by increased alveolar permeability with no effective treatment beyond supportive care. Current mechanisms underlying… Expand
Self-Sterilizing Laser-Induced Graphene Bacterial Air Filter.
Nosocomial infections transmitted through airborne, droplet, aerosol, and particulate-transported modes pose substantial infection risks to patients and healthcare employees. In this study, we… Expand
A review of decellularized stem cell matrix: a novel cell expansion system for cartilage tissue engineering.
Cell-based therapy is a promising biological approach for the treatment of cartilage defects. Due to the small size of autologous cartilage samples available for cell transplantation in patients,… Expand
IL-17 A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
Bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in B cells and de novo follicular lymphoma.
- G. Vanasse, R. Winn, +8 authors J. Harlan
- Medicine, Biology
- Molecular cancer research : MCR
- 1 November 2004
The t(14;18)(q32;q21), resulting in deregulated expression of B-cell-leukemia/lymphoma-2 (Bcl-2), represents the genetic hallmark in human follicular lymphomas. Substantial evidence supports the… Expand
Effective Treatment of Mouse Sepsis With an Inhibitory Antibody Targeting Integrin &agr;v&bgr;5*
Objective:Integrin &agr;v&bgr;5 has been identified as a regulator of vascular leak and endothelial permeability. We hypothesized that targeting &agr;v&bgr;5 could represent a viable treatment… Expand
Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.
- K. Tsujino, J. Li, +4 authors D. Sheppard
- Medicine, Biology
- American journal of physiology. Lung cellular and…
- 1 November 2017
Mice that globally overexpress the transcription factor Fos-related antigen-2 (Fra-2) develop extensive pulmonary fibrosis and pulmonary vascular remodeling. To determine if these phenotypes are a… Expand