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Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
Inhibiting signal transduction induced by inflammatory cytokines offers a new approach for the treatment of autoimmune diseases such as rheumatoid arthritis. Kinase inhibitors have shown promisingExpand
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Ruminal and intestinal amino acid digestion of distiller's grain vary with grain source and milling process
a b s t r a c t A study was conducted to evaluate the in situ ruminal degradability of crude protein (CP), amino acid (AA) profiles of ruminal undegradable protein (RUP), and in vitro intestinalExpand
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Phylogenetic position of the enigmatic Lepidogalaxias salamandroides with comment on the orders of lower euteleostean fishes.
This study examines phylogenetic placement of the enigmatic Western Australian Lepidogalaxias, and extends previous studies by including eight new taxa to enable re-examination phylogeneticExpand
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miR-7 reverses the resistance to BRAFi in melanoma by targeting EGFR/IGF-1R/CRAF and inhibiting the MAPK and PI3K/AKT signaling pathways
MicroRNAs (miRNAs) are attractive therapeutic targets for various therapy-resistant tumors. However, the association between miRNA and BRAF inhibitor resistance in melanoma remains to be elucidated.Expand
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Downregulation of miR-138 Sustains NF-κB Activation and Promotes Lipid Raft Formation in Esophageal Squamous Cell Carcinoma
Purpose: Constitutive activation of NF-κB signaling plays vital roles in esophageal squamous cell carcinoma (ESCC) progression. The aim of this study was to evaluate the effect of miR-138 on NF-κBExpand
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CXCL11-Armed oncolytic poxvirus elicits potent antitumor immunity and shows enhanced therapeutic efficacy
ABSTRACT We have armed a tumor-selective oncolytic vaccinia virus (vvDD) with the chemokine (CK) CXCL11, in order to enhance its ability to attract CXCR3+ antitumor CTLs and possibly NK cells to theExpand
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Tuning defects in oxides at room temperature by lithium reduction
Defects can greatly influence the properties of oxide materials; however, facile defect engineering of oxides at room temperature remains challenging. The generation of defects in oxides is difficultExpand
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A new method for detecting human recombination hotspots and its applications to the HapMap ENCODE data.
Computational detection of recombination hotspots from population polymorphism data is important both for understanding the nature of recombination and for applications such as association studies.Expand
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Biochar stability assessment methods: A review.
Biochar is being developed as a candidate with great potential for climate change mitigation. Sequestering biochar carbon in soil contributes greatly to the reduction of greenhouse gases emissions,Expand
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Use of microalgae to recycle nutrients in aqueous phase derived from hydrothermal liquefaction process.
Hydrothermal liquefaction (HTL) of microalgae biomass generates an aqueous phase (AP) byproduct with limited energy value. Recycling the AP solution as a source of nutrients for microalgaeExpand
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