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A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
During infection, vertebrates develop “sickness syndrome,” characterized by fever, anorexia, behavioral withdrawal, acute-phase protein responses, and inflammation. These pathophysiological responsesExpand
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Phylogenetic Patterns in Northern Hemisphere Plant Geography
Geological and climatological processes that have impacted the biota of the Northern Hemisphere during the Tertiary are expected to yield little resolution when area cladograms are compared withoutExpand
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MD-2 is required for disulfide HMGB1–dependent TLR4 signaling
Yang et al. show that a disulfide isoform of HMGB1, with a role in TLR4 signaling, physically interacts with and binds MD-2. MD-2 deficiency in macrophage cell lines or in primary mouse macrophagesExpand
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High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization
High mobility group box protein 1 (HMGB1), a DNA binding nuclear and cytosolic protein, is a proinflammatory cytokine released by monocytes and macrophages. This study addressed the hypothesis thatExpand
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Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment
ABSTRACT Autophagy is a conserved eukaryotic mechanism that mediates the removal of long-lived cytoplasmic macromolecules and damaged organelles via a lysosomal degradative pathway. Recently, aExpand
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Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the interferon-induced antiviral response. In this study, we report that interferon-α (IFN-α) induced theExpand
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TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons.
  • J. Xing, J. Li
  • Chemistry, Medicine
  • Journal of neurophysiology
  • 2007
The purpose of this study was to determine the role of transient receptor potential vanilloid type 1 (TRPV1) receptor in modulating neuronal activity of the dorsolateral periaqueductal gray (dl-PAG)Expand
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Oxytocin is an anabolic bone hormone
We report that oxytocin (OT), a primitive neurohypophyseal hormone, hitherto thought solely to modulate lactation and social bonding, is a direct regulator of bone mass. Deletion of OT or the OTExpand
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An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases.
The hepatitis B virus (HBV) is a DNA virus that can cause chronic hepatitis B (CHB) in humans. Current therapies for CHB infection are limited in efficacy and do not target the pre-existing viralExpand
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ATP concentrations and muscle tension increase linearly with muscle contraction.
Previous studies have suggested that activation of ATP-sensitive P2X receptors in skeletal muscle play a role in mediating the exercise pressor reflex (Li J and Sinoway LI. Am J Physiol Heart CircExpand
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