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The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.
The first preclinical evaluation of the next-generation ALK TKI, ceritinib (LDK378), in the setting of crizotinib resistance demonstrates that ceritInib can overcome crizotib resistance, consistent with clinical data showing marked efficacy of cerit inib in patients with crizotonib-resistant disease. Expand
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas.
This study profiles the shifting RNA landscape of gliomas during progression and reveled ZM as a novel, recurrent fusion transcript in sGBMs and revealed that the fusion arose from translocation events involving introns 3 or 8 of PTPRZ and intron 1 of MET. Expand
A family of molecules related to collapsin in the embryonic chick nervous system
The discovery of four new molecules related to collapsin in chick brains that contain a semaphorin domain and could potentially act as repulsive cues toward specific neuronal populations. Expand
Characterization of summer organic and inorganic aerosols in Beijing, China with an Aerosol Chemical Speciation Monitor
Abstract An Aerodyne Aerosol Chemical Speciation Monitor (ACSM) was first deployed in Beijing, China for characterization of summer organic and inorganic aerosols. The non-refractory submicronExpand
Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons.
The connectivity between CS neurons in the forelimb motor and sensory cortices and various spinal interneurons is mapped, demonstrating that distinct CS-interneuron circuits control specific aspects of skilled movements. Expand
Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
It is shown that receptor-mediated endocytosis in neurons by the low-density lipoprotein receptor-related protein 1 (LRP1) plays a critical role in brain Aβ clearance and indicates that neurons not only produce but also clear Aβ. Expand
Emerging Role for Autophagy in the Removal of Aggresomes in Schwann Cells
It is shown that Schwann cells have the ability to eliminate aggresomes by a mechanism that is enhanced when autophagy is activated and is primarily prevented when autophileagy is inhibited, linking the proteasomal and lysosomal protein degradation pathways. Expand
Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma
Combined EGFR and DRD2 inhibition led to synergistic tumoricidal activity as well as ERK suppression in independent in vivo and in vitro glioblastoma models, and suggest combined EGFR-Dopamine Receptor D2 inhibition as a promising strategy for gliOBlastoma treatment. Expand
Pacemaker Neurons within Newborn Spinal Pain Circuits
  • J. Li, M. Baccei
  • Biology, Medicine
  • The Journal of Neuroscience
  • 15 June 2011
Evidence is provided that a subpopulation of glutamatergic interneurons within lamina I of the rat spinal cord exhibits oscillatory burst firing during early life, which occurs independently of fast synaptic transmission. Expand
LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β
It is demonstrated that Aβ can be cleared locally in the cerebrovasculature by an LRP1-dependent endocytic pathway in smooth muscle cells and a disturbance of this pathway contributes to Aβ accumulation. Expand