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Imaging oxygenation of human tumours
Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive… Expand
Standardized methods for the production of high specific-activity zirconium-89.
Zirconium-89 is an attractive metallo-radionuclide for use in immuno-PET due to favorable decay characteristics. Standardized methods for the routine production and isolation of high-purity and… Expand
Imaging biomarker roadmap for cancer studies
- J. O’Connor, E. Aboagye, +74 authors J. C. Waterton
- Nature Reviews Clinical Oncology
- 11 October 2016
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection… Expand
Copper radionuclides and radiopharmaceuticals in nuclear medicine.
The chemistry, radiochemistry, radiobiology, and radiopharmacology of radiopharmaceuticals containing copper radionuclides are reviewed. Copper radionuclides offer application in positron emission… Expand
Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model.
- J. Lewis, D. W. Mccarthy, T. McCarthy, Y. Fujibayashi, M. Welch
- Journal of nuclear medicine : official…
UNLABELLED We have evaluated Cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM), an effective marker for the delineation of hypoxic but viable tissue, in vitro in the EMT6 carcinoma cell line… Expand
89Zr-DFO-J591 for ImmunoPET of Prostate-Specific Membrane Antigen Expression In Vivo
- J. Holland, V. Divilov, N. Bander, P. Smith-Jones, S. Larson, J. Lewis
- Chemistry, Medicine
- The Journal of Nuclear Medicine
- 1 August 2010
89Zr (half-life, 78.41 h) is a positron-emitting radionuclide that displays excellent potential for use in the design and synthesis of radioimmunoconjugates for immunoPET. In the current study, we… Expand
A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy.
- K. Chao, W. Bosch, +7 authors M. Welch
- International journal of radiation oncology…
- 15 March 2001
PURPOSE Locoregional tumor control for locally advanced cancers with radiation therapy has been unsatisfactory. This is in part associated with the phenomenon of tumor hypoxia. Assessing hypoxia in… Expand
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
- K. Moulick, J. H. Ahn, +25 authors G. Chiosis
- Biology, Medicine
- Nature chemical biology
- 1 November 2011
Most cancers are characterized by multiple molecular alterations, but identification of the key proteins involved in these signaling pathways is currently beyond reach. We show that the inhibitor… Expand
Cerenkov Luminescence Imaging of Medical Isotopes
- A. Ruggiero, J. Holland, J. Lewis, J. Grimm
- Materials Science, Medicine
- Journal of Nuclear Medicine
- 1 July 2010
The development of novel multimodality imaging agents and techniques represents the current frontier of research in the field of medical imaging science. However, the combination of nuclear… Expand
Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity
The bacteriophage population is large, dynamic, ancient, and genetically diverse. Limited genomic information shows that phage genomes are mosaic, and the genetic architecture of phage populations… Expand