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Regulation of Histone Acetylation during Memory Formation in the Hippocampus*
Results indicate that histone-associated heterochromatin undergoes changes in structure during the formation of long term memory, which enhances a cellular process thought to underlie longterm memory formation, hippocampal long term potentiation, and memory formation itself. Expand
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice.
The data demonstrate that MeCP2 levels must be tightly regulated in vivo, and that even mild overexpression of this protein is detrimental, and support the possibility that duplications or gain-of-function mutations in MECP2 might underlie some cases of X-linked delayed-onset neurobehavioral disorders. Expand
Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome
Very early symptomatic Mecp2308/Y mice had increased basal synaptic transmission and deficits in the induction of long-term depression, suggesting that functional and ultrastructural synaptic dysfunction is an early event in the pathogenesis of RTT. Expand
Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus*
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of enduring cellular memory. Stable patterns of DNA methylation are established during development, resulting inExpand
ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning.
Changes in histone phosphorylation in the hippocampus are regulated by ERK/MAPK following a behavioral fear conditioning paradigm, and injection of an inhibitor of MEK (MAP kinase/ERK kinase), the unique dual-specificity kinase upstream of ERK, blocked the increase in histones or DNA seen after contextual fear conditioning. Expand
Levels of Serotonin in the Hemolymph of AplysiaAre Modulated by Light/Dark Cycles and Sensitization Training
It is proposed that 5- HT has a humoral role in regulation of the behavioral state of Aplysia and found that increasing levels of 5-HT in the hemolymph led to significant alterations in feeding behavior. Expand
Epigenetic mechanisms in memory formation
Neurobiologists have only recently begun to investigate the possible roles of epigenetic mechanisms in behaviour, physiology and neuropathology, and relevant data from the few extant neurobiology-related studies have already indicated a theme — epigenetic mechanism probably have an important role in synaptic plasticity and memory formation. Expand
Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake
Results indicate that regulation of glutamate uptake may be important for maintaining the level of synaptic strength during long-term changes in synaptic efficacy. Expand
A Bioinformatics Analysis of Memory Consolidation Reveals Involvement of the Transcription Factor c-Rel
It is found that regulatory elements for several transcription factors are over-represented in the upstream region of genes regulated during consolidation of LTM, and c-rel, one of the transcription factors identified in the bioinformatics study, is necessary for hippocampus-dependent long-term memory formation. Expand
c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation.
It is found that contextual fear conditioning elicited a time-dependent increase in nuclear c-Rel levels in area CA1 and DG of hippocampus, which suggests that c-rel is active in regulating transcription during memory consolidation. Expand