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Sample size calculations in clinical research.
The specific goal of this (2nd edition) book continues to be to provide a comprehensive and unified presentation regarding sample size calculations in a variety of clinical research and developmentExpand
Human cardiovascular and metabolic response to acute, severe isovolemic anemia.
Analysis of Holter readings suggests that at this Hb concentration in this resting healthy population, myocardial ischemia would occur infrequently, and does not produce evidence of inadequate systemic TO2, as assessed by lack of change of VO2 and plasma lactate concentration. Expand
Relative Importance of Preoperative Health Status Versus Intraoperative Factors in Predicting Postoperative Adverse Outcomes in Geriatric Surgical Patients
The study demonstrates that the postoperative mortality rate in geriatric surgical patients undergoing noncardiac surgery is low, and despite the prevalence of preoperative chronic medical conditions, most patients do well postoperatively. Expand
Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization.
It is concluded that proinflammatory cytokines are elevated after uncomplicated coronary revascularization and may contribute to postoperative myocardial ischemia and segmental wall motion abnormalities. Expand
Perioperative cognitive decline in the aging population.
A road map to further elucidate the mechanisms, diagnosis, risk factors, mitigation, and treatment of postoperative cognitive decline in the elderly is provided. Expand
An Update on Postoperative Cognitive Dysfunction.
This work states that whether patients with early POCD actually have preexisting mild cognitive impairment and experience a steeper downward cognitive trajectory independent of the effect of anesthesia and surgery is another question that warrants further investigation and advocate for a theoretically derived and empirically tested model which describes the causes and outcomes of P OCD. Expand
Postoperative delirium in older adults: best practice statement from the American Geriatrics Society.
This article is a supplement to the American Geriatrics Soci Practice Guidelines for Postoperative Delirium in Older Adu presented at the American College of Surgeons 100 Annual Clinic San Francisco, CA, October 2014. Expand
Postoperative Delirium: The Importance of Pain and Pain Management
The hypothesis that pain and pain management strategies are important factors related to the development of postoperative delirium in elderly patients is validated. Expand
Predicting Adverse Postoperative Outcomes in Patients Aged 80 Years or Older
This study compared the relative importance of intraoperative versus preoperative factors in predicting adverse postoperative outcomes in geriatric patients to identify reversible factors that are associated with postoperative morbidity. Expand
The effects of postoperative pain and its management on postoperative cognitive dysfunction.
Older patients undergoing noncardiac surgery who are not delirious can experience significant declines in cognitive functioning postoperatively, and those who received postoperative analgesia orally were at significantly lower risk for the development of POCD. Expand