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Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling.
- P. Metcalfe, J. Leslie, M. Campbell, D. Meldrum, K. Hile, K. Meldrum
- Medicine, Biology
- American journal of physiology. Endocrinology and…
- 1 February 2008
Upper urinary tract obstruction is a common cause of renal dysfunction in children and adults. While there is clinical evidence of an increased male incidence and mortality rate with acute renal… Expand
The role of interleukin-18 in renal injury.
Interleukin (IL)-18 is a relatively new pro-inflammatory cytokine, formerly known as interferon-gamma-inducing factor, which induces interferon-gamma production in T cells and natural killer cells.… Expand
TNF-alpha neutralization decreases nuclear factor-kappaB activation and apoptosis during renal obstruction.
- K. Meldrum, P. Metcalfe, J. Leslie, R. Misseri, K. Hile, D. Meldrum
- The Journal of surgical research
BACKGROUND Obstruction of the upper urinary tract is an important cause of progressive renal injury in children. While tumor necrosis factor-alpha (TNF-alpha) and nuclear factor kappaB (NFkappaB)… Expand
Creation of continence mechanisms (Mitrofanoff) without appendix: the Monti and spiral Monti procedures.
This is a review of the technique to create a continent catheterizable stoma using the Yang-Monti principle of a transversely tubularized segment of bowel. Pediatric urologists have widely used this… Expand
Corporeal grafting for severe hypospadias: a single institution experience with 3 techniques.
- J. Leslie, M. Cain, M. Kaefer, K. Meldrum, R. Misseri, R. Rink
- The Journal of urology
- 1 October 2008
PURPOSE Correction of severe chordee by corporeal body grafting has been successfully performed using various grafts and biomaterials. We report a single institution comparison of our experience… Expand
TNF-α neutralization decreases nuclear factor-κB activation and apoptosis during renal obstruction
Background Obstruction of the upper urinary tract is an important cause of progressive renal injury in children. While tumor necrosis factor-α (TNF-α) and nuclear factor κB (NFκB) have independently… Expand
Serendipitous renal cell carcinoma in the post-CT era: continued evidence in improved outcomes.
PURPOSE To compare patient and tumor characteristics, including survival data, between serendipitous and non-serendipitously discovered renal cell carcinoma (RCCA) in an era of more frequent use of… Expand
A comparison of the Monti and Casale (spiral Monti) procedures.
PURPOSE We present our long-term followup and comparison of outcomes between the Monti and Casale (spiral Monti) procedures in a large group of children and young adults. MATERIALS AND METHODS A… Expand
Feminizing genital reconstruction in congenital adrenal hyperplasia
The past several decades have seen multiple advances in the surgical reconstruction for girls born with Disorders of Sexual Differentiation. This surgery can be technically very demanding, and must… Expand
Pediatric urologic emergencies and urgencies.
The more common urologic problems seen in infancy and childhood that require urgent or emergent pediatric urologic referral are discussed, including a brief description of the usual presenting signs… Expand