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Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues.
TLDR
This extensive study showed that the pattern of (iso) enzymes was different in all tissues studied; consequently, xenobiotic metabolism would appear to be very different in each type of tissue. Expand
The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA.
TLDR
It is concluded that modified nucleotides have a predominant role in canonical folding of human mitochondrial tRNALys and a major contribution of m1A9 in this process is argued. Expand
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.
TLDR
P-450 1A2 and P-450 3A4 are the major enzymes involved in imipramine N-demethylation in human hepatic microsomes, and these results suggest that interindividual variations in3A4 hepatic content may explain the large variations in imIPramine blood levels observed after uniform dosages and thus explain the variations in clinical efficacy. Expand
Cytochrome P-450 monooxygenase activities in human and rat liver microsomes.
TLDR
The monooxygenase activities, the sensitivity to in vitro alpha-naphthoflavone and metyrapone, the results of steroid metabolism, and slab gel electrophoresis are strong indications for multiplicity of human liver cytochrome P-450. Expand
Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.
TLDR
It is shown that among the macromolecules present in human adult liver microsomes, one protein called cytochrome P-450-8 is specifically recognized by most sera of patients containing anti-LKM2 antibodies but not by control serum, suggesting a possible mechanism for the appearance of anti-organelle antibodies in a drug-induced hepatitis. Expand
Deletions of mitochondrial DNA in Kearns-Sayre syndrome and ocular myopathies: Genetic, biochemical and morphological studies
TLDR
A good relationship between the cytochrome c oxidase deficiency and the amount of deleted mtDNA was shown in the present investigations. Expand
Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes.
TLDR
The results clearly suggest that multiple mechanisms are involved in the regulation of different drug-metabolizing enzymes in the human fetus. Expand
Molecular analysis of carnitine palmitoyltransferase II deficiency with hepatocardiomuscular expression.
TLDR
Data show that CPT II activity has to be reduced below a critical threshold in order for LCFA oxidation in fibroblasts to be impaired, and the hypothesis that this critical threshold differs among tissues could provide a basis to explain phenotypic heterogeneity of C PT II deficiency. Expand
Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene.
TLDR
Data show that modified nucleotides contribute to efficient isoleucylation and point mutation A4269G in the gene, associated with a cardiomyopathy, does not affect aminoacylation significantly, while A4317G, reported in a case of fatal infantile cardiopathy, induces a small but significant decrease in isoleUcylation. Expand
Enzymatic and immunological characterization of cytochromes P 450 from ellipticine-treated rat liver.
TLDR
Ellipticine belongs to the polycyclic aromatic hydrocarbon type of cytochrome P 450 inducers, however, the extent of induction by ellipticine was lower than that by 5,6-benzoflavone. Expand
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