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The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA.
It is concluded that modified nucleotides have a predominant role in canonical folding of human mitochondrial tRNALys and a major contribution of m1A9 in this process is argued.
Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues.
- I. de Waziers, P. Cugnenc, C. S. Yang, J. Leroux, P. Beaune
- Biology, MedicineThe Journal of pharmacology and experimental…
- 1 April 1990
This extensive study showed that the pattern of (iso) enzymes was different in all tissues studied; consequently, xenobiotic metabolism would appear to be very different in each type of tissue.
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.
P-450 1A2 and P-450 3A4 are the major enzymes involved in imipramine N-demethylation in human hepatic microsomes, and these results suggest that interindividual variations in3A4 hepatic content may explain the large variations in imIPramine blood levels observed after uniform dosages and thus explain the variations in clinical efficacy.
Cytochrome P-450 monooxygenase activities in human and rat liver microsomes.
The monooxygenase activities, the sensitivity to in vitro alpha-naphthoflavone and metyrapone, the results of steroid metabolism, and slab gel electrophoresis are strong indications for multiplicity of human liver cytochrome P-450.
Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.
- P. Beaune, P. Dansette, J. Homberg
- Biology, MedicineProceedings of the National Academy of Sciences…
It is shown that among the macromolecules present in human adult liver microsomes, one protein called cytochrome P-450-8 is specifically recognized by most sera of patients containing anti-LKM2 antibodies but not by control serum, suggesting a possible mechanism for the appearance of anti-organelle antibodies in a drug-induced hepatitis.
Deletions of mitochondrial DNA in Kearns-Sayre syndrome and ocular myopathies: Genetic, biochemical and morphological studies
Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene.
- T. Cresteil, P. Beaune, C. Célier, J. Leroux, F. Guengerich
- Biology, ChemistryThe Journal of pharmacology and experimental…
Pretreatment with phenobarbital resulted in the precocious onset of PB-B in fetal and neonatal rat liver accompanied by an increase in classically associated monooxygenase activities, which was significantly increased by 3-methylcholanthrene whatever the age considered.
Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes.
- T. Cresteil, P. Beaune, P. Kremers, C. Célier, F. Guengerich, J. Leroux
- Biology, ChemistryEuropean journal of biochemistry
- 1 September 1985
The results clearly suggest that multiple mechanisms are involved in the regulation of different drug-metabolizing enzymes in the human fetus.
Molecular analysis of carnitine palmitoyltransferase II deficiency with hepatocardiomuscular expression.
Data show that CPT II activity has to be reduced below a critical threshold in order for LCFA oxidation in fibroblasts to be impaired, and the hypothesis that this critical threshold differs among tissues could provide a basis to explain phenotypic heterogeneity of C PT II deficiency.
Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene.
Data show that modified nucleotides contribute to efficient isoleucylation and point mutation A4269G in the gene, associated with a cardiomyopathy, does not affect aminoacylation significantly, while A4317G, reported in a case of fatal infantile cardiopathy, induces a small but significant decrease in isoleUcylation.