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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
TLDR
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed. Expand
Selective degradation of mitochondria by mitophagy.
TLDR
The term mitophagy is used to refer to mitochondrial degradation by autophagy, and the possible role of the mitochondrial permeability transition in mitophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover. Expand
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
TLDR
In vitro findings suggest that the MPT is the pathophysiological mechanism underlying Reye's syndrome in vivo, and a model is proposed in which onset of theMPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death. Expand
Mechanisms of hepatotoxicity.
TLDR
This review addresses recent advances in specific mechanisms of hepatotoxicity, including inducible nitric oxide synthase knockout mice, where nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead. Expand
Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties.
TLDR
Inhibition of mitochondria ATPase likely accounts for the cytotoxicity of Rhodamine 123, a sensitive and specific probe of delta psi in isolated mitochondria at concentrations which do not inhibit mitochondrial function. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
TLDR
The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death. Expand
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
TLDR
NADPH oxidase mediates the actions of Ang II on HSCs and plays a critical role in liver fibrogenesis, as assessed by microarray analysis. Expand
Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.
TLDR
Hepatocytes cultured in a collagen-sandwich configuration for up to 5 days establish intact canalicular networks, maintain Mrp2, reestablish polarized excretion of organic anions and bile acids, and represent a useful in vitro model system to investigate the hepatobiliary disposition of substrates. Expand
Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.
TLDR
The MPT is a common pathway leading to both nec rotic and apoptotic cell death after ischemia/reperfusion, and the balance between ATP depletion after the MPT and ATP generation by glycolysis determines whether the fate of cells will be apoptotic or necrotic death. Expand
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