J. Leigh

Publications266
h-index63
Citations14,885
Highly Influential Citations507
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Magnetic resonance imaging of perfusion using spin inversion of arterial water.
TLDR
Perfusion images of a freeze-injured rat brain have been obtained, demonstrating the technique's ability to detect regional abnormalities in perfusion.
Perfusion imaging.
TLDR
This technique allows regional perfusion maps to be measured noninvasively, with the resolution of 1H MRI, and should be readily applicable to human studies.
Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles.
TLDR
The results support studies that showed decreases in muscle metabolism with age in healthy humans and show a good correlation between in vivo and in vitro measurements of oxidative metabolism.
Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function.
TLDR
The concept of transfer function for organ performance (work output vs. biochemical input) is developed for skeletal and cardiac muscle under steady-state exercise conditions and appears to be useful in predicting the degree to which metabolic homeostasis is effective.
Simultaneous in vivo measurements of HbO2 saturation and PCr kinetics after exercise in normal humans.
TLDR
Simultaneous measurements of phosphocreatine (PCr) and oxyhemoglobin (HbO2) saturation were made during recovery from exercise in calf muscles of five male subjects to conclude that magnetic resonance spectroscopy measurements of PCr recovery and near-infrared spectroscopic measurements of recovery of HbO 2 saturation provide similar information as long as muscle pH remains near 7.0.
Noninvasive measurement of phosphocreatine recovery kinetics in single human muscles.
The rate at which phosphocreatine (PCr) is resynthesized after exercise is related to muscle oxidative capacity (Vmax). With the use of a one-dimensional image-guided, localized nuclear magnetic…
In vivo ATP synthesis rates in single human muscles during high intensity exercise
TLDR
In vivo ATP utilization rates and the initial dependence on PCr and glycolysis were similar to those previously reported in in situ studies involving short duration, high intensity exercise, and the observation that glycogenolytic and glyCOlytic rates are elevated in vivo in the presence of elevated Pi levels is supported.
Tissue specific perfusion imaging using arterial spin labeling
TLDR
This approach allows quantitative perfusion images to be obtained completely non‐invasively at the resolution of 1H MRI, and is useful in the clinical and investigational evaluation of organ physiology.
Sodium MRI of human articular cartilage in vivo
TLDR
In vivo sodium MRI of human patellar articular cartilage provides the first evidence that sodium imaging may be used to detect changes due to osteoarthritis in vivo, and the process of optimizing imaging time and signal‐to‐noise ratio is discussed.
Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain.
TLDR
Time-resolved spectroscopy afforded a display of the times and distances of arrival of photons emitted by the cat brain in response to a 10-ps input pulse, and deoxyhemoglobin can be quantified in brain tissues.
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