J. Leigh

Publications266
h-index63
Citations14,336
Highly Influential Citations505
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Magnetic resonance imaging of perfusion using spin inversion of arterial water.
A technique has been developed for proton magnetic resonance imaging (MRI) of perfusion, using water as a freely diffusable tracer, and its application to the measurement of cerebral blood flow (CBF)… Expand
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Perfusion imaging.
Measurement of tissue perfusion is important for the functional assessment of organs in vivo. Here we report the use of 1H NMR imaging to generate perfusion maps in the rat brain at 4.7 T. Blood… Expand
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Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles.
This study compared in vivo measurements of muscle metabolism in humans with magnetic resonance spectroscopy (MRS) and in vitro analysis of biopsies. Healthy subjects [4 young males, 28.2 +/- 6.8… Expand
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Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function.
The concept of transfer function for organ performance (work output vs. biochemical input) is developed for skeletal and cardiac muscle under steady-state exercise conditions. For metabolic control… Expand
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Simultaneous in vivo measurements of HbO2 saturation and PCr kinetics after exercise in normal humans.
Simultaneous measurements of phosphocreatine (PCr) and oxyhemoglobin (HbO2) saturation were made during recovery from exercise in calf muscles of five male subjects. PCr was measured using magnetic… Expand
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Noninvasive measurement of phosphocreatine recovery kinetics in single human muscles.
The rate at which phosphocreatine (PCr) is resynthesized after exercise is related to muscle oxidative capacity (Vmax). With the use of a one-dimensional image-guided, localized nuclear magnetic… Expand
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In vivo ATP synthesis rates in single human muscles during high intensity exercise
1 In vivo ATP synthesis rates were measured in the human medial gastrocnemius muscle during high intensity exercise using localized 31P‐magnetic resonance spectroscopy (31P‐MRS). Six‐second localized… Expand
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Tissue specific perfusion imaging using arterial spin labeling
Quantitative magnetic resonance measurements of regional tissue perfusion can be obtained using magnetically labeled arterial water as a diffusable tracer. Continuous labeling is achieved in flowing… Expand
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Magnetic resonance imaging of the brain: Blood partition coefficient for water: Application to spin‐tagging measurement of perfusion
We describe the use of relative proton density imaging to obtain spatially resolved measurements of the brain:blood partition coefficient for water. Values of relative proton density and apparent‐T1… Expand
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Sodium MRI of human articular cartilage in vivo
Preliminary results from in vivo sodium MRI of human patellar articular cartilage are presented. Sodium images generated of an in vitro bovine patella clearly distinguish the region of proteoglycan… Expand
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