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Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term
TLDR
In this study, celecoxib, at dosages greater than those indicated clinically, was associated with a lower incidence of symptomatic ulcers and ulcer complications combined, as well as other clinically important toxic effects, compared with NSAIDs at standard dosages. Expand
Arachidonic acid metabolism.
TLDR
C YC LOO XYGENASE PRODUC TS . . . LOOXYgenase PROD UC . Expand
Comparison of thromboembolic events in patients treated with celecoxib, a cyclooxygenase-2 specific inhibitor, versus ibuprofen or diclofenac.
TLDR
The hypothesis of a class adverse effect of cyclooxygenase 2 specific inhibitors on the CV system is not supported and the incidences of adverse CV events such as hypertension, edema, and congestive heart failure were similar to, or significantly lower than, NSAID comparators regardless of the use of ASA. Expand
Celecoxib versus diclofenac in the management of osteoarthritis of the knee.
TLDR
Celecoxib 200 mg daily is as effective as diclofenac 150 mg daily for relieving signs and symptoms of OA of the knee, including pain, and has a rapid onset of action, but celecoxib appears to have a superior safety and tolerability profile. Expand
A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee.
TLDR
Patients with osteoarthritis of the hip or knee had significantly greater improvements in pain scores over 6 weeks with diclofenac + misoprostol than with acetaminophen, although patients with mild osteOarthritis had similar improvements with both drugs. Expand
Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA
TLDR
Bacterial DNA has immunological properties that attenuate murine lupus despite the induction of pathogenic antibodies, suggesting a special potency of foreign DNA in inducing serological manifestations of l upus in a susceptible host. Expand
Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib.
TLDR
The findings indicate that the intolerance reaction in AIA is due to inhibition of COX-1, while the highest recommended daily dose of celecoxib was well tolerated, with no symptoms, lung function changes, or alterations in urinary LTE(4) levels. Expand
Chemokines are expressed in a myeloid cell-dependent fashion and mediate distinct functions in immune complex glomerulonephritis in rat.
TLDR
The influx of myeloid cells is necessary for local chemokine expression in anti-glomerular basement membrane nephritis, although the differential expression of CXC and CC chemokines must involve additional factors. Expand
Immune complex-stimulated neutrophil LTB4 production is dependent on beta 2 integrins
TLDR
A role for the beta 2 integrins in a signal transduction pathway leading to sustained adhesion and LTB4 production in response to IC is identified, suggesting cooperation between these receptors in generating PMN activation in Response to IC stimulation. Expand
Effects of Celecoxib on Ambulatory Blood Pressure in Hypertensive Patients on ACE Inhibitors
TLDR
It is demonstrated that high doses of celecoxib have no significant effect on the antihypertensive effect of the ACE inhibitor lisinopril, and changes in the 24-hour BP, body weight, and clinical laboratory parameters were assessed. Expand
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