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Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments.
Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation of local inflammatory events through… Expand
Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis
- J. Lees, P. Golumbek, J. Sim, D. Dorsey, J. H. Russell
- Biology, Medicine
- The Journal of experimental medicine
- 27 October 2008
The localization of inflammatory foci within the cerebellum is correlated to severe clinical outcomes in multiple sclerosis (MS). Previous studies of experimental autoimmune encephalomyelitis (EAE),… Expand
Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites
Immunization with irradiated sporozoites is currently the most effective vaccination strategy against liver stages of malaria parasites, yet the mechanisms underpinning the success of this approach… Expand
Host T Cells Are the Main Producers of IL-17 within the Central Nervous System during Initiation of Experimental Autoimmune Encephalomyelitis Induced by Adoptive Transfer of Th1 Cell Lines1
Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, has long been thought to be mediated by Th1 CD4+ T cells. Using adoptive transfer techniques, transfer of CNS… Expand
Deletion is neither sufficient nor necessary for the induction of peripheral tolerance in mature CD8+ T cells
Previous reports have demonstrated clonal deletion of CD8+ T cells during peripheral tolerance induction to tissue antigens. However, direct evidence demonstrating a causal connection between… Expand
Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells.
Expanded polyclonal T regulatory cells (Tregs) offer great promise for the treatment of immune-mediated diseases. Inhibition by Tregs is under the control of the T-cell receptor (TCR). Therefore, we… Expand
A little stress is good: IFN-γ, demyelination, and multiple sclerosis
The exact role(s) of the cytokine IFN-γ in the demyelinating disease multiple sclerosis remain controversial, with evidence suggesting both detrimental and protective effects of the cytokine in MS… Expand
T‐cell recognition of a prostate specific antigen is not sufficient to induce prostate tissue destruction
The ability of CD8+ T‐cells to induce prostate inflammation was examined using a prostate ovalbumin expressing transgenic mouse (POET) and/or adoptive transfer of T‐cell receptor (TCR) transgenic… Expand
A little stress is good: IFN-gamma, demyelination, and multiple sclerosis.
The exact role(s) of the cytokine IFN-gamma in the demyelinating disease multiple sclerosis remain controversial, with evidence suggesting both detrimental and protective effects of the cytokine in… Expand
Myeloid derived suppressor cells in transplantation.
Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we… Expand