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Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments.
Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation of local inflammatory events through… Expand
Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis
- J. Lees, P. Golumbek, J. Sim, D. Dorsey, J. Russell
- Biology, Medicine
- The Journal of experimental medicine
- 27 October 2008
It is demonstrated, using an adoptive transfer system, that the ability of the central nervous system (CNS) to sense pathogenic T cell–produced IFN-γ during EAE initiation determines the sites of CNS pathogenesis. Expand
Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites
It is found that sporozoite antigen persists for over 8 weeks after immunization—a remarkable finding since irradiated sporozoites are incapable of replication and do not differentiate beyond early liver stages. Expand
Pulmonary Surfactant Protein A Activates a Phosphatidylinositol 3-Kinase/Calcium Signal Transduction Pathway in Human Macrophages: Participation in the Up-Regulation of Mannose Receptor Activity1
- A. Beharka, Joy E. Crowther, +4 authors L. Schlesinger
- Biology, Medicine
- The Journal of Immunology
- 15 August 2005
It is shown that SP-A induces signal transduction pathway(s) that impact on MR expression that involves the activation of a pathway in which PI3K is a component, and that both the attached sugars and the collagen-like domain ofSP-A are necessary to optimize Ca2+ mobilization. Expand
Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells.
It is shown that engineered clonal MBP-specific Tregs are able to suppress autoimmune pathology in EAE, and may serve as a cellular therapy for MS patients with the common DR15 haplotype that is associated with disease susceptibility. Expand
A little stress is good: IFN-gamma, demyelination, and multiple sclerosis.
Evidence is produced that protective effects of IFN-gamma on mature oligodendrocytes during EAE induction are mediated via activation of the pancreatic ER kinase (PERK), resulting in induction of the endoplasmic reticular stress response pathway. Expand
Deletion is neither sufficient nor necessary for the induction of peripheral tolerance in mature CD8+ T cells
It is demonstrated that deletion is neither sufficient nor required for CD8+ T‐cell tolerance to tissue antigens, suggesting that regulatory events independent of deletion are necessary for peripheral tolerance induction to prostate antigENS. Expand
A little stress is good: IFN-γ, demyelination, and multiple sclerosis
Evidence is produced that protective effects of IFN-γ on mature oligodendrocytes during EAE induction are mediated via activation of the pancreatic ER kinase (PERK), resulting in induction of the endoplasmic reticular stress response pathway. Expand
Host T Cells Are the Main Producers of IL-17 within the Central Nervous System during Initiation of Experimental Autoimmune Encephalomyelitis Induced by Adoptive Transfer of Th1 Cell Lines1
It is demonstrated that an encephalitogenic Th1 cell line induces recruitment of host IL-17-producing T cells to the CNS during the initiation of EAE and that these cells contribute to the incidence and severity of disease. Expand
Generation, persistence and plasticity of CD4 T‐cell memories
Findings in CD4 T‐cell memory suggest inherent plasticity in populations of memory T cells at all stages of their development, including during their persistence and homeostatic turnover in response to T‐ cell receptor signals, and also following secondary challenge. Expand