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Molecular gas in elliptical galaxies
Observations of 24 early-type galaxies, mostly far-infrared (FIR)-bright ellipticals, in the 12 CO(2-1) emission line resulted in 10 detections including eight out of the 20 elliptical. Eight of… Expand
Protein disulfide Isomerase Acts as a Molecular Chaperone during the Assembly of Procollagen*
It is demonstrated that PDI has multiple functions in the folding of the same protein, that is, as a catalyst for disulfide bond formation, as an subunit of P4-H during proline hydroxylation, and independently as a molecular chaperone during chain assembly. Expand
The structure and organization of the human heavy neurofilament subunit (NF‐H) and the gene encoding it.
- J. Lees, P. S. Shneidman, S. Skuntz, M. Carden, R. Lazzarini
- Biology, Medicine
- The EMBO journal
- 1 July 1988
Genomic clones for the largest human neurofilament protein (NF‐H) were isolated, the intron/exon boundaries mapped and the entire protein‐coding regions (exons) sequenced, revealing a repetitive sequence that covers more than half its length and includes the sequence motif, Lys‐Ser‐Pro (KSP) greater than 40 times. Expand
mRNA levels of all three neurofilament proteins decline following nerve transection.
- M. Goldstein, S. R. Weiss, R. Lazzarini, P. S. Shneidman, J. Lees, W. Schlaepfer
- Biology, Medicine
- Brain research
- 1 June 1988
The early and co-terminal fall in mRNAs suggests that the 3 NF genes are regulated by common factor(s) and that the function of these factors is influenced by the state of axonal continuity with the target organ. Expand
Nucleotide sequence of the Bunyamwera virus M RNA segment: conservation of structural features in the Bunyavirus glycoprotein gene product.
The complete nucleotide sequence of the Bunyamwera virus M RNA segment was determined from four overlapping cDNA clones and by primer extension, and it is presumed that the three proteins G1, G2, and NSM are synthesized as a precursor polyprotein which is subsequently proteolytically cleaved. Expand
Identification of the molecular recognition sequence which determines the type‐specific assembly of procollagen
This work has identified a discontinuous sequence of 15 amino acids which directs procollagen self‐association and can direct chain association and, potentially, assemble molecules with defined chain compositions. Expand
The C‐propeptide domain of procollagen can be replaced with a transmembrane domain without affecting trimer formation or collagen triple helix folding during biosynthesis
It is shown that the C‐propeptide domain directs the initial association event and is required to allow triple helix formation, but the essential function of this domain does not include double helix nucleation or alignment. Expand
The Orbital Structure of Galactic Halos
Earlier numerical experiments have shown that the orbital structure in the halo of a triaxial logarithmic potential differs significantly from that in the main body of the potential; the usual box… Expand
Type-III procollagen assembly in semi-intact cells: chain association, nucleation and triple-helix folding do not require formation of inter-chain disulphide bonds but triple-helix nucleation does…
Results indicate that inter-chain disulphide bond formation within the C-propeptide or the C -telopeptide is not required for chain association and triple-helix formation. Expand
Genome subunit reassortment among Bunyaviruses analysed by dot hybridization using molecularly cloned complementary DNA probes.
It was concluded that restriction was mediated at the gene product level and that nonrandom reassortment was not due to incompatibility of genome subunits. Expand