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Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis
Defining the functional modules within transcriptional regulatory factors that govern switching between repression and activation events is a central issue in biology. Recently, we have reported the… Expand
EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.
Ubiquitination plays a major role in protein degradation. Although phosphorylation-dependent ubiquitination is well known for the regulation of protein stability, methylation-dependent ubiquitination… Expand
RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer.
Wnt family members play diverse roles in development and disease. Noncanonical Wnt ligands can inhibit canonical Wnt signaling depending on the cellular context; however, the underlying mechanism of… Expand
Negative regulation of hypoxic responses via induced Reptin methylation.
Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to… Expand
Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino.
- Hyun-Mi Oh, Sung-Kyu Choi, +6 authors B. Kwon
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 November 2005
Four cyclopentenediones, farnesyl protein transferase inhibitors, and anti-tumor compounds were isolated from the methanolic extract of the fruits of Lindera erythrocarpa Makino (Lauraceae). The… Expand
Aberrant expression of let-7a miRNA in the blood of non-small cell lung cancer patients.
- Hye Cheol Jeong, E. Kim, J. H. Lee, J. Lee, Han Na Yoo, J. K. Kim
- Biology, Medicine
- Molecular medicine reports
- 1 March 2011
Abnormal expression of let-7a microRNA (miRNA) in non-small cell lung cancer (NSCLC) cells and tissue has been previously reported. Our objective was to investigate whether let-7a miRNA is aberrantly… Expand
DNA damage-induced RORα is crucial for p53 stabilization and increased apoptosis.
A critical component of the DNA damage response is the p53 tumor suppressor, and aberrant p53 function leads to uncontrolled cell proliferation and malignancy. Several molecules have been shown to… Expand
Clinical Outcomes Following Implantation of Diffractive Multifocal Intraocular Lenses With Varying Add Powers.
- J. Kim, J. W. Jung, J. Lee, K. Seo, E. Kim, T. Kim
- American journal of ophthalmology
- 1 October 2015
PURPOSE To compare clinical outcomes after implantation of TECNIS diffractive multifocal intraocular lenses (IOLs) with different add powers. DESIGN Prospective, comparative, interventional case… Expand
The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity
- Yang Woon Lee, K. Lee, +5 authors C. Paik
- The Korean journal of internal medicine
- 20 January 2018
Background/Aims Fecal calprotectin (FC) is known to correlate with disease activity and can be used as a predictor for relapse or treatment response in inflammatory bowel disease (IBD). We evaluated… Expand
Crohn's disease in Korea: past, present, and future
The epidemiology, genetics, and clinical manifestations of Crohn's disease (CD) vary considerably among geographic areas and ethnic groups. Thus, identifying the characteristics of Korean CD is… Expand