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Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea
In the presence of obesity, β-cell mass needs to be increased to compensate for the accompanying demands and maintain euglycemia. However, in Korea, the majority of type 2 diabetic patients are… Expand
Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea.
- K. Yoon, Seung Hyun Ko, +12 authors S. Bonner-Weir
- The Journal of clinical endocrinology and…
In the presence of obesity, beta-cell mass needs to be increased to compensate for the accompanying demands and maintain euglycemia. However, in Korea, the majority of type 2 diabetic patients are… Expand
Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance.
BACKGROUND/AIMS During the natural course of hepatitis B virus (HBV) infection, the long-term clinical and histological outcomes following spontaneous hepatitis B surface antigen (HBsAg)… Expand
Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Lipopolysaccharide-Induced TNF-α Production in THP-1 Cells and Endotoxin Shock in Mice1
- Han Geun Kim, Nara Kim, +6 authors D. Chung
- Biology, Medicine
- The Journal of Immunology
- 15 February 2008
In this study, the effect of Lactobacillus plantarum lipoteichoic acid (pLTA) on LPS-induced MAPK activation, NF-κB activation, and the expression of TNF-α and IL-1R-associated kinase M (IRAK-M) was… Expand
Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells
Objective: To investigate the molecular basis of drug resistance in pancreatic cancer. Methods: The expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) levels in pancreatic cancer… Expand
Dexamethasone coordinately regulates angiopoietin-1 and VEGF: a mechanism of glucocorticoid-induced stabilization of blood-brain barrier.
Glucocorticoids stabilize the blood-brain barrier (BBB), leading to attenuation of vasogenic brain edema. However, the action mechanism of glucocorticoids has been poorly elucidated. To elucidate the… Expand
Episodic Exposure to Fine Particulate Air Pollution Decreases Circulating Levels of Endothelial Progenitor Cells
Rationale: Acute and chronic exposures to airborne particulate matter (PM) have been linked in epidemiological studies to a wide spectrum of cardiovascular disorders that are characterized by a… Expand
Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor
- J. H. Lee, J. Lee, +6 authors C. Hong
- Medicine, Chemistry
- Archives of pharmacal research
- 1 October 1998
We developed a novel water-soluble camptothecin analogue, CKD602, and evaluated the inhibition of topoisomerase I and the antitumor activities against mammalian tumor cells and human tumor… Expand
Proposed cytotoxic mechanisms of the saffron carotenoids crocin and crocetin on cancer cell lines.
- Se Hyeuk Kim, J. Lee, S. Kim, C. B. Park, P. Lee
- Chemistry, Medicine
- Biochemistry and cell biology = Biochimie et…
- 29 January 2014
We investigated the cytotoxic activities of crocin and crocetin, 2 major carotenoids isolated from the stigma of Crocus sativus (saffron), on 5 human cancer cell lines and proposed their possible… Expand
Survival outcomes of hepatic resection compared with transarterial chemoembolization or sorafenib for hepatocellular carcinoma with portal vein tumor thrombosis
Background/Aims: Treating hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remains controversial. We compared the outcomes of hepatic resection (HR), transarterial… Expand