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Genotoxicity and endocrine-disruption potentials of sediment near an oil spill site: two years after the Hebei Spirit oil spill.
- K. Ji, Jihyeon Seo, +11 authors K. Choi
- Biology, Medicine
- Environmental science & technology
- 5 August 2011
The Hebei Spirit oil spill episode (December 7, 2007) has affected the western coastal area of South Korea; however, there is limited information on the potential toxicity of the oil spill to the… Expand
Zebrafish as a model for investigating developmental lead (Pb) neurotoxicity as a risk factor in adult neurodegenerative disease: a mini-review.
Lead (Pb) exposure has long been recognized to cause neurological alterations in both adults and children. While most of the studies in adults are related to higher dose exposure, epidemiological… Expand
Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment.
Genotoxic potentials and the mechanisms of six pharmaceuticals, which are frequently detected in surface water worldwide, were investigated using isogenic chicken DT40 mutant cell lines. These… Expand
Zebrafish as a Model for Developmental Neurotoxicity Assessment: The Application of the Zebrafish in Defining the Effects of Arsenic, Methylmercury, or Lead on Early Neurodevelopment
Developmental exposure to neurotoxic chemicals presents significant health concerns because of the vulnerability of the developing central nervous system (CNS) and the immature brain barrier. To… Expand
Protective immunity against Naegleria fowleri infection on mice immunized with the rNfa1 protein using mucosal adjuvants
The free-living amoeba, Naegleria fowleri, causes a fatal disease called primary amoebic meningoencephalitis (PAM) in humans and experimental animals. Of the pathogenic mechanism of N. fowleri… Expand
Indications and Surgical Results of Twist-Drill Craniostomy at the Pre-Coronal Point for Symptomatic Chronic Subdural Hematoma Patients
- J. Lee, Bum-Tae Kim, Sun-Chul Hwang, Soo-Bin Im, Dong-Seong Shin, Wonhan Shin
- Journal of Korean Neurosurgical Society
- 1 August 2012
Objective Twist-drill craniostomy (TDC) with closed-system drainage and burr-hole drainage (BHD) with a closed system are effective treatment options for chronic subdural hematoma (CSDH). The aim of… Expand
Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen-1 in Myanmar isolates
BackgroundPlasmodium falciparum apical membrane antigen-1 (PfAMA-1) is one of leading blood stage malaria vaccine candidates. However, genetic variation and antigenic diversity identified in global… Expand
Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax.
- Jung-Mi Kang, Jung-Won Ju, +7 authors B. Na
- Biology, Medicine
- Protein expression and purification
- 1 April 2015
Methionine aminopeptidases (MetAPs), ubiquitous enzymes that play an important role in nascent protein maturation, have been recognized as attractive targets for the development of drugs against… Expand
Lead (Pb) exposure reduces global DNA methylation level by non-competitive inhibition and alteration of dnmt expression.
- O. Sanchez, J. Lee, Nathaphon Yu King Hing, Seong-Eun Kim, Jennifer L. Freeman, Chongli Yuan
- Biology, Medicine
- Metallomics : integrated biometal science
- 22 February 2017
Low-dose exposure to lead (Pb) is connected to developmental neurological alterations by inducing molecular changes, such as aberrant gene expression patterns. The attributing molecular mechanism,… Expand
Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory–secretory proteins and their biochemical properties
Naegleria fowleri causes a lethal primary amoebic meningoencephalitis (PAM) in humans and experimental animals, which leads to death within 7–14 days. Cysteine proteases of parasites play key roles… Expand