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UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke
Helicases use the energy derived from nucleoside triphosphate hydrolysis to unwind double helices in essentially every metabolic pathway involving nucleic acids. Earlier crystal structures have… Expand
Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity.
DNA and a large proportion of RNA are antiparallel duplexes composed of an unvarying phosphosugar backbone surrounding uniformly stacked and highly similar base pairs. How do the myriad of enzymes… Expand
Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications.
- J. Lee, Chris A Bashur, A. Goldstein, C. Schmidt
- Medicine, Materials Science
- 1 September 2009
Electrospinning is a promising approach to create nanofiber structures that are capable of supporting adhesion and guiding extension of neurons for nerve regeneration. Concurrently, electrical… Expand
Structure and mechanism of human DNA polymerase η
This corrects the article DOI: 10.1038/nature09196
High-resolution crystal structure of the non-specific lipid-transfer protein from maize seedlings.
BACKGROUND The movement of lipids between membranes is aided by lipid-transfer proteins (LTPs). Some LTPs exhibit broad specificity, transferring many classes of lipids, and are termed non-specific… Expand
Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
Non-specific lipid-transfer proteins (nsLTPs) are involved in the movement of phospholipids, glycolipids, fatty acids, and steroids between membranes. Several structures of plant nsLTPs have been… Expand
Integral Q-learning and explorized policy iteration for adaptive optimal control of continuous-time linear systems
This paper proposes an integral Q-learning for continuous-time (CT) linear time-invariant (LTI) systems, which solves a linear quadratic regulation (LQR) problem in real time for a given system and a… Expand
Integral Reinforcement Learning for Continuous-Time Input-Affine Nonlinear Systems With Simultaneous Invariant Explorations
- J. Lee, J. Park, Y. Choi
- Computer Science, Medicine
- IEEE Transactions on Neural Networks and Learning…
- 1 May 2015
This paper focuses on a class of reinforcement learning (RL) algorithms, named integral RL (I-RL), that solve continuous-time (CT) nonlinear optimal control problems with input-affine system… Expand
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7
- K. Kim, D. An, +13 authors S. Suh
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 30 April 2012
The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis (Msm) in… Expand
Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family
Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their… Expand