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Multifunctional in vivo vascular imaging using near-infrared II fluorescence
In vivo real-time epifluorescence imaging of mouse hind limb vasculatures in the second near-infrared region (NIR-II) is performed using single-walled carbon nanotubes as fluorophores. Both highExpand
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Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity.
Human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) are promising for treatment of vascular diseases. However, hiPSC-ECs purified based on CD31 expression are comprised ofExpand
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Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8
Significance Here, we are reporting our findings that hypoxia-inducible factor 1 (HIF-1) activation in monocytes promotes neovascularization in matrigel and improves blood flow in hindlimb ischemiaExpand
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Endothelial Cells Derived From Human iPSCS Increase Capillary Density and Improve Perfusion in a Mouse Model of Peripheral Arterial Disease
Objective—Stem cell therapy for angiogenesis and vascular regeneration has been investigated using adult or embryonic stem cells. In the present study, we investigated the potential of endothelialExpand
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Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements
SummaryDespite the possibility that tumour hypoxia may limit radiotherapeutic response, the underlying mechanisms remain poorly understood. A new methodology has been developed in which informationExpand
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Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis.
The objective of this study was to enhance the angiogenic capacity of endothelial cells (ECs) using nanoscale signaling cues from aligned nanofibrillar scaffolds in the setting of tissue ischemia.Expand
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Stress intensity factors for cracks of arbitrary shape near an interfacial boundary
Abstract Modes I, II and III stress intensity factors for a crack of arbitrary planar shape near a bimaterial interface are calculated. The solution utilizes the body-force method and requiresExpand
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Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts
While the potential importance of hypoxia in limiting the sensitivity of tumor cells to ionizing radiation has long been appreciated, methods for accurately quantifying the number ofExpand
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Conversion of Human Fibroblasts to Functional Endothelial Cells by Defined Factors
  • J. Li, N. Huang, +5 authors S. Ding
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 June 2013
Objective—Transdifferentiation of fibroblasts to endothelial cells (ECs) may provide a novel therapeutic avenue for diseases, including ischemia and fibrosis. Here, we demonstrate that humanExpand
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Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment.
Microenvironmental conditions within solid tumors can have marked effects on the growth of the tumors and their response to therapies. The disorganized growth of tumors and their attendant vascularExpand
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