• Publications
  • Influence
Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods
The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant Klebsiella pneumoniaeExpand
  • 246
  • 29
Investigation of a Nosocomial Outbreak of Imipenem-Resistant Acinetobacter baumannii Producing the OXA-23 β-Lactamase in Korea
ABSTRACT We investigated an outbreak of Acinetobacter baumannii in an intensive care unit and in the surgery, medicine, neurology, and urology wards of the Kosin University Gospel Hospital in Busan,Expand
  • 152
  • 12
Molecular Characterization of Extended-Spectrum Beta-Lactamases Produced by Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from a Korean Nationwide Survey
ABSTRACT To determine the prevalence and genotypes of extended-spectrum beta-lactamases (ESBLs) among clinical isolates of Klebsiella pneumoniae and Escherichia coli, we performed antibioticExpand
  • 118
  • 8
Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase.
The emergence and dissemination of extended-spectrum (ES) beta-lactamases induce therapeutic failure and a lack of eradication of clinical isolates even by third-generation beta-lactam antibioticsExpand
  • 97
  • 8
Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options
  • C. Lee, J. Lee, +6 authors S. Lee
  • Medicine, Biology
  • Front. Cell. Infect. Microbiol.
  • 13 March 2017
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible for hospital-acquired nosocomial infections in the modern healthcare system. Due to the prevalence ofExpand
  • 178
  • 7
Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms
  • C. Lee, J. Lee, +5 authors S. Lee
  • Medicine, Biology
  • Front. Cell. Infect. Microbiol.
  • 21 November 2017
Klebsiella pneumoniae is one of the most clinically relevant species in immunocompromised individuals responsible for community-acquired and nosocomial infections, including pneumonias, urinary tractExpand
  • 85
  • 7
The Epidemiology of Appendicitis and Appendectomy in South Korea: National Registry Data
Background Appendicitis is one of the most frequent acute surgical conditions of the abdomen, and appendectomy is one of the most commonly performed operations in the world. However, epidemiologicalExpand
  • 123
  • 5
A conserved region in the sigma54-dependent activator DctD is involved in both binding to RNA polymerase and coupling ATP hydrolysis to activation.
Rhizobium melioti DctD activates transcription from the dctA promoter by catalysing the isomerization of closed complexes between sigma54-RNA polymerase holoenzyme and the promoter to open complexes.Expand
  • 53
  • 5
Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints
BackgroundAdipose tissue-derived stem cells (ADSCs), a type of mesenchymal stem cells (MSCs), have great potential as therapeutic agents in regenerative medicine. Numerous animal studies haveExpand
  • 107
  • 4
Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance
  • J. H. Jeon, J. Lee, +5 authors S. Lee
  • Biology, Medicine
  • International journal of molecular sciences
  • 29 April 2015
Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β-lactams and are primarily used toExpand
  • 76
  • 4