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Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02)
TLDR
It is hypothesized that plasma-based EGFR mutation analysis for NSCLC may be feasible for monitoring treatment response to EGFR TKIs and also predict drug resistance and more studies are warranted to guide optimal therapeutic strategies upon knowledge of treatment response and resistance.
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Hepatitis B reactivation in multiple myeloma patients with resolved hepatitis B undergoing chemotherapy
  • J. Lee, S. Lim, Kihyun Kim
  • Biology, Medicine
    Liver international : official journal of the…
  • 1 November 2015
TLDR
Despite increasing reports of hepatitis B virus (HBV) reactivation in multiple myeloma (MM), HBV reactivating in patients with resolved hepatitis B is still poorly characterized and its frequency and risk factors are unclear.
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Anti-inflammatory activity of arctigenin from Forsythiae Fructus.
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Acquired C797S Mutation upon Treatment with a T790M-Specific Third-Generation EGFR Inhibitor (HM61713) in Non-Small Cell Lung Cancer.
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Anti-inflammatory action of phenolic compounds fromGastrodia elata root
TLDR
Results indicate that phenolic compounds of GE are anti-inflammatory, which may be related to inhibition of COX activity and to anti-oxidant activity.
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Methylation of the mouse DIx5 and Osx gene promoters regulates cell type-specific gene expression.
TLDR
Findings suggest that DNA methylation plays an important role in cell type-specific expression of Dlx5 and Osx in osteogenic and nonosteogenic cell lines.
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Optical coherence tomography angiography vessel density mapping at various retinal layers in healthy and normal tension glaucoma eyes
TLDR
Understanding of the spatial characteristics of peripapillary vasculature may be helpful in clinical practice and determining the optimal measurement area of vessel density.
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Association Between PD-L1 and HPV Status and the Prognostic Value of PD-L1 in Oropharyngeal Squamous Cell Carcinoma
  • H. Kim, J. Lee, M. Ahn
  • Biology, Medicine
    Cancer research and treatment : official journal…
  • 15 September 2015
TLDR
Large prospective studies are required to determine the role of PD-L1 expression as a prognostic or predictive biomarker, and clinical studies of immune checkpoint inhibitors in OCSS are warranted regardless of HPV status.
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MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis
TLDR
The study suggests that MCT4 is a clinically relevant target in GC with peritoneal carcinomatosis and its silencing resulted in reduced tumor cell proliferation and lactate uptake in malignant ascites.
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Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis.
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