J. Lederberg

Publications4,319
h-index65
Citations19,160
Highly Influential Citations299
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Microbial Threats to Health: Emergence, Detection, and Response
TLDR
The sobering conclusion is made, ten years after the IOM report on Emerging infections that the global burden of infectious disease on the United States has actually increased.
Emerging Infections: Microbial Threats to Health in the United States
TLDR
Rich in information, this volume highlights risk factors for the emergence of microbial threats to health, warns against complacency in public health, and promotes early prevention as a cost-effective and crucial strategy for maintaining public health in the United States and worldwide.
GENETIC EXCHANGE IN SALMONELLA
TLDR
The mechanism of genetic exchange found in these experiments differs from sexual recombination in E. coli in many respect’s so as to warrant a new descriptive term, transduction.
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REPLICA PLATING AND INDIRECT SELECTION OF BACTERIAL MUTANTS
TLDR
An approach to this problem that makes use of a replica plating technique which facilitates the handling of large numbers of bacterial clones for classification on a variety of media is concerned.
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Applications of Artificial Intelligence for Organic Chemistry: The DENDRAL Project
TLDR
In the terms of the paradigm of problem solving, abstraction can be achieved by defining a new set of problem-state descriptions, based on a language that is an abstrac34 APPLICATIONS of ARTIFICIAL INTELLIGENCE for organic chemistry fororganic chemistry, in the sense that one problem- state description in the abstraction language corresponds to many problem-State descriptions in the basic language.
Gene Recombination in Escherichia Coli
ANALYSIS of mixed cultures of nutritional mutants has revealed the presence of new types which strongly suggest the occurrence of a sexual process in the bacterium, Escherichia coli.
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Infectious History
In 1530, to express his ideas on the origin of syphilis, the Italian physician Girolamo Fracastoro penned Syphilis, sive morbus Gallicus (Syphilis, or the French disease) in verse. In it he taught…
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Cell genetics and hereditary symbiosis.
TLDR
This review is an attempt to reconcile the attitudes that plasmids are symbiotic organisms, and that they comprise part of the genetic determination of the organic whole, in organisms whose germ and soma are not irreversibly differentiated.
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`Ome Sweet `Omics--A Genealogical Treasury of Words
Gene Recombination in the Bacterium Escherichia coli
TLDR
This paper will be devoted to the presentation of evidence for the occurrence in a bacterium of a process of gene recombination, from which the existence of a sexual stage may be inferred.
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