J. Leckman

Publications714
h-index135
Citations60,823
Highly Influential Citations2,346
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The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity.
TLDR
Data from 105 subjects support the construct, convergent, and discriminant validity of the instrument, and indicate that the YGTSS is a promising instrument for the assessment of tic severity in children, adolescents and adults.
Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity.
TLDR
The CY-BOCS yields reliable and valid subscale and total scores for obsessive-compulsive symptom severity in children and adolescents with OCD and may be influenced by age of the child and the hazards associated with integrating data from parental and patient sources.
Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
TLDR
Findings support the association of rare SLITRK1 sequence variants with TS by identifying a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189.
Ritual, habit, and perfectionism: the prevalence and development of compulsive-like behavior in normal young children.
TLDR
A parent-report questionnaire, the Childhood Routines Inventory (CRI), was developed to assess compulsive-like behavior in young children, and was administered to 1,492 parents with children between the ages of 8 and 72 months.
A multidimensional model of obsessive-compulsive disorder.
TLDR
The complex clinical presentation of OCD can be summarized with a few consistent, temporally stable symptom dimensions that can be understood as a spectrum of potentially overlapping syndromes that may coexist in any patient, be continuous with normal obsessive-compulsive phenomena, and extend beyond the traditional nosological boundaries of OCD.
Genes and behavior: nature–nurture interplay explained.
Symptoms of obsessive-compulsive disorder.
TLDR
The four symptom dimensions identified in this study are largely congruent with those identified in earlier reports, and may be of value in future genetic, neurobiological, and treatment response studies.
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
TLDR
It is shown that Fgf2 is expressed in the pseudostratified ventricular epithelium (PVE) in a dorsoventral gradient and that Ff2 and its receptor, Fgfr-1, are downregulated by mid to late stages of neurogenesis.
A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.
TLDR
Guanfacine appears to be a safe and effective treatment for children with tic disorders and ADHD.
From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric
TLDR
Modifying the PANDAS criteria to eliminate etiologic factors and to clarify the initial clinical presentation produced three potential diagnostic criteria for PANS, which are discussed in detail.
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