J. Leckman

Publications658
h-index129
Citations53,135
Highly Influential Citations2,236
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The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity.
Despite the overt nature of most motor and phonic tic phenomena, the development of valid and reliable scales to rate tic severity has been an elusive goal. The Yale Global Tic Severity Scale (YGTSS)… Expand
  • 1,519
  • 209
Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity.
OBJECTIVE To evaluate the reliability and validity of a semistructured measure of obsessive-compulsive symptom severity in children and adolescents with obsessive-compulsive disorder (OCD). METHOD… Expand
  • 1,396
  • 152
Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as a candidate… Expand
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  • 54
  • PDF
Ritual, habit, and perfectionism: the prevalence and development of compulsive-like behavior in normal young children.
Young children engage in a significant amount of ritualistic, repetitive, and compulsive-like activity that appears to be part of their normal behavioral repertoire. Empirically, little is known… Expand
  • 350
  • 43
A multidimensional model of obsessive-compulsive disorder.
OBJECTIVE Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. This heterogeneity can reduce the power and obscure the findings from natural history studies to genome scans,… Expand
  • 784
  • 38
  • PDF
Symptoms of obsessive-compulsive disorder.
OBJECTIVE Obsessive-compulsive disorder encompasses a broad range of symptoms that represent multiple psychological domains, including perception, cognition, emotion, social relatedness, and diverse… Expand
  • 647
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Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Little is known about regionally specific signals that control the number of neuronal progenitor cells in vivo. We have previously shown that the germline mutation of the basic fibroblast growth… Expand
  • 388
  • 31
Practitioner Review: Engaging fathers – recommendations for a game change in parenting interventions based on a systematic review of the global evidence
Background Despite robust evidence of fathers’ impact on children and mothers, engaging with fathers is one of the least well-explored and articulated aspects of parenting interventions. It is… Expand
  • 286
  • 30
  • PDF
A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.
OBJECTIVE This study evaluated the efficacy and safety of guanfacine in treating children with tic disorders and attention deficit hyperactivity disorder (ADHD). METHOD Subjects from a specialty… Expand
  • 487
  • 27
A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands.
In a family study of 1,254 adult relatives of patients and controls, lifetime prevalences of major affective disorder (including schizoaffective) were 37%, 24%, 25%, 20% and 7% in relatives of… Expand
  • 863
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