The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity.
Data from 105 subjects support the construct, convergent, and discriminant validity of the instrument, and indicate that the YGTSS is a promising instrument for the assessment of tic severity in children, adolescents and adults.
Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity.
- L. Scahill, M. Riddle, J. Leckman
- Psychology, MedicineJournal of the American Academy of Child and…
- 1 June 1997
The CY-BOCS yields reliable and valid subscale and total scores for obsessive-compulsive symptom severity in children and adolescents with OCD and may be influenced by age of the child and the hazards associated with integrating data from parental and patient sources.
Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
Findings support the association of rare SLITRK1 sequence variants with TS by identifying a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189.
Ritual, habit, and perfectionism: the prevalence and development of compulsive-like behavior in normal young children.
A parent-report questionnaire, the Childhood Routines Inventory (CRI), was developed to assess compulsive-like behavior in young children, and was administered to 1,492 parents with children between the ages of 8 and 72 months.
Genes and behavior: nature–nurture interplay explained.
- J. Leckman
- 1 February 2007
A multidimensional model of obsessive-compulsive disorder.
- D. Mataix-Cols, M. Rosário-Campos, J. Leckman
- PsychologyAmerican Journal of Psychiatry
- 1 February 2005
The complex clinical presentation of OCD can be summarized with a few consistent, temporally stable symptom dimensions that can be understood as a spectrum of potentially overlapping syndromes that may coexist in any patient, be continuous with normal obsessive-compulsive phenomena, and extend beyond the traditional nosological boundaries of OCD.
Nurturing care: promoting early childhood development
Symptoms of obsessive-compulsive disorder.
The four symptom dimensions identified in this study are largely congruent with those identified in earlier reports, and may be of value in future genetic, neurobiological, and treatment response studies.
A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.
Guanfacine appears to be a safe and effective treatment for children with tic disorders and ADHD.
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
- R. Raballo, J. Rhee, R. Lyn-Cook, J. Leckman, M. Schwartz, F. Vaccarino
- BiologyJournal of Neuroscience
- 1 July 2000
It is shown that Fgf2 is expressed in the pseudostratified ventricular epithelium (PVE) in a dorsoventral gradient and that Ff2 and its receptor, Fgfr-1, are downregulated by mid to late stages of neurogenesis.