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Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans.
According to in-vitro studies with microsomes from human livers and from yeast expression systems with high CYP2D6 activity, the major oxidation pathway of venlafaxine is catalysed by CYP2D6. In thisExpand
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Surgical management and radiological characteristics of bronchogenic cysts.
Forty-two patients with bronchogenic cysts were treated over a 30-year period (1962 to 1991). The location was mediastinal in 37 and intrapulmonary in 5. Cysts were symptomatic in 21 patients (50%)Expand
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Man in the cold
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Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats.
The effects of exercise training and food restriction on the regulation of lipolysis were studied comparatively in adipocytes isolated from male and female rats. Exercise training inhibited cellExpand
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Diphenhydramine Alters the Disposition of Venlafaxine Through Inhibition of CYP2D6 Activity in Humans
CYP2D6 is the major enzyme involved in the metabolism of venlafaxine. Subjects with a low CYP2D6 activity have increased plasma concentrations of venlafaxine that may predispose them toExpand
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Transaxillary pleurectomy for treatment of spontaneous pneumothorax.
In the 16-year period 1962 to 1978, 409 transaxillary apical pleurectomies were carried out for definitive treatment of spontaneous pneumothorax in 362 patients. Surgical indications includedExpand
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Role of palatability on meal-induced thermogenesis in human subjects.
To study the possible participation of food-induced sensory stimulation on meal thermogenesis an experiment was performed with eight female subjects. On alternate days subjects were fed either aExpand
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Effects of age, sex, and physical fitness on responses to local cooling.
The response to local cooling was estimated by the cold hand test (5 degrees C for 2 min) and the cold face test (0 degrees C with 66 km.h-1 wind for 2 min). Heart rate, blood pressure, and skinExpand
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Tolerance of Gaspe fishermen to cold water.
A group of Gaspe fishermen used to cold water immersion and control subjects from the same vicinity were studied to determine if the fishermen's hands were adapted to cold. With one hand immersed i...
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Ipsilateral acoustic reflex stimulation in normal and sensorineural impaired ears: a preliminary report.
Ipsilateral acoustic reflex thresholds were measured at 1,000 Hz and 2,000 Hz in 38 subjects with normal hearing and in 107 subjects with a symmetrical sensorineural hearing loss. Acoustic reflexExpand
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