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- Publications
- Influence
Immunological factors and risk of infection in plateau phase myeloma.
- R. Hargreaves, J. Lea, +6 authors H. Chapel
- Biology, Medicine
- Journal of clinical pathology
- 1 March 1995
AIMS--A series of patients with myeloma were investigated to assess whether immunological risk factors predisposing to serious infection could be identified. METHODS--Patients (n = 102) with… Expand
Predictors of infection in chronic lymphocytic leukaemia (CLL)
- H. Griffiths, J. Lea, C. Bunch, M. Lee, H. Chapel
- Medicine
- Clinical and experimental immunology
- 1 September 1992
A group of patients with chronic lymphocytic leukaemia (CLL) were studied to determine whether particular clinical and laboratory parameters might help to identify those patients at risk of recurrent… Expand
Simplified high performance liquid chromatographic method for the determination of clonazepam and other benzodiazepines in serum.
- V. Haver, W. Porter, L. D. Dorie, J. Lea
- Chemistry, Medicine
- Therapeutic drug monitoring
- 1986
A convenient and sensitive high performance liquid chromatographic method was developed for determination of clonazepam in serum using a C-18 reverse-phase column, and mobile phase consisting of a… Expand
Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors
- H. Griffiths, V. Brennan, J. Lea, C. Bunch, M. Lee, H. Chapel
- Medicine
- 1 February 1989
A randomized crossover study of prophylactic immunoglobulin (IgG) therapy was performed in patients with chronic lymphocytic leukaemia (CLL) or non-Hodgkin's lymphoma (NHL). Twelve patients with… Expand
Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors.
- H. Griffiths, V. Brennan, J. Lea, C. Bunch, M. Lee, H. Chapel
- Medicine
- Blood
- 1989
A randomized crossover study of prophylactic immunoglobulin (IgG) therapy was performed in patients with chronic lymphocytic leukaemia (CLL) or non-Hodgkin's lymphoma (NHL). Twelve patients with… Expand
Ligand-dependent tryptic inactivation of the ouabain sensitivity of ADP-ATP exchange catalyzed by canine renal Na+, K+-ATPase.
- J. Lea, C. G. Winter
- Chemistry, Medicine
- Biochemical and biophysical research…
- 6 June 1977
Abstract Trypsin treatment of purified canine renal Na+,K+-ATPase preparations causes loss of Na+,K+-ATPase activity with production of tryptic fragments as described previously (Jorgensen, P. L.… Expand
Hypogammaglobulinaemia in low grade B cell tumours; significance and therapy.
- H. Chapel, H. Griffiths, V. Brennan, C. Bunch, J. Lea, M. Lee
- Medicine
- Immunological investigations
- 1 April 1991
Bacterial infection is an important cause of morbidity and mortality in patients with B-cell tumors; this is related to their secondary hypogammaglobulinaemia. Two studies of intravenous replacement… Expand
Kinetics and mechanism of electrophilic substitution of heteroaromatic compounds. Part XXIII. Acid-catalysed hydrogen exchange of quinoline, isoquinoline, and their N-oxides
- U. Bressel, A. Katritzky, J. Lea
- Chemistry
- 1971
Rate profiles are reported for the title reactions. Exchanges are shown to proceed on the conjugate acid species at various positions in the carbocyclic rings. Exchange in the heterocyclic rings… Expand
Kinetics and mechanism of electrophilic substitution of heteroaromatic compounds. Part XXIV. Acid-catalysed hydrogen exchange of 2-naphthol and of some corresponding aza-, thia-, and oxo-derivatives
- U. Bressel, A. Katritzky, J. Lea
- Chemistry
- 1971
The variation of rate with acidity is studied for the hydrogen exchange of 2-naphthol at the 1-position, for 6-amino-, 6-hydroxy-, and 6-methoxy-quinoline and for the 6-hydroxy-1-methylquinolinium… Expand