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Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish.
The zebrafish is a useful model organism for developmental and genetic studies. The morphology and function of zebrafish myeloid cells were characterized. Adult zebrafish contain 2 distinct… Expand
Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning.
The mammalian transcription factor SPI-1 (synonyms: SPI1, PU.1, or Sfpi1) plays a critical role in myeloid development. To examine early myeloid commitment in the zebrafish embryo, we isolated a gene… Expand
Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation.
- R. Williams, P. Senior, L. V. Van Stekelenburg, J. Layton, P. Smith, M. Dziadek
- Medicine, Biology
- Biochimica et biophysica acta
- 1 April 2002
Stromal interaction molecule 1 (STIM1) is a cell surface transmembrane glycoprotein implicated in tumour growth control and stromal-haematopoietic cell interactions. A single sterile alpha motif… Expand
Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.
- S. Nicholson, A. Oates, A. Harpur, A. Ziemiecki, A. Wilks, J. Layton
- Chemistry, Biology
- Proceedings of the National Academy of Sciences…
- 12 April 1994
Granulocyte-colony-stimulating factor (G-CSF) stimulates the proliferation and differentiation of cells of the neutrophil lineage by interaction with a specific receptor. Early signal transduction… Expand
Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers.
To define an optimal regimen for mobilizing and collecting peripheral blood progenitor cells (PBPC) for use in allogeneic transplantation, we evaluated the kinetics of mobilization by filgrastim… Expand
Evidence for a novel in vivo control mechanism of granulopoiesis: mature cell-related control of a regulatory growth factor
As part of phase I/II clinical trials of granulocyte colony-stimulating factor (G-CSF), the pharmacokinetics was studied. To determine the optimal way of abrogating the neutropenia caused by… Expand
Endogenous haemopoietic growth factors in neutropenia and infection
Summary Haemopoietic growth factors (HGFs) are being administered to patients with neutropenic fever; however, little is known about the endogenous HGF response in these patients. Specific assays… Expand
Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK.
The protein tyrosine kinases JAK1 and JAK2 are phosphorylated tyrosine after the interaction of granulocyte colony-stimulating factor (G-CSF) with its transmembrane receptor. So too is Stat3, a… Expand
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.
- L. Pase, J. Layton, W. Kloosterman, D. Carradice, P. Waterhouse, G. Lieschke
- Biology, Medicine
- 19 February 2009
We demonstrate that in zebrafish, the microRNA miR-451 plays a crucial role in promoting erythroid maturation, in part via its target transcript gata2. Zebrafish miR-144 and miR-451 are processed… Expand
Continuous plasmafiltration in sepsis syndrome
Objective:To assess the effect of plasmafiltration (PF) on biochemical markers of inflammation, cytokines, organ dysfunction, and 14-day mortality in human sepsis.Design:Multicenter, prospective,… Expand