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Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.
Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase [cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the inducible COX-2 in humans,Expand
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A2
It is shown that injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2receptor but are depressed in mice genetically deficiencies in the TxA2 receptor (TP) or treated with a TP antagonist. Expand
COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice
It is reported that estrogen acts on estrogen receptor subtype alpha to up-regulate the production of atheroprotective prostacyclin, PGI2, by activation of cyclooxygenase 2 (COX-2), which restrained both oxidant stress and platelet activation that contribute to atherogenesis in female mice. Expand
Obesity in mice with adipocyte-specific deletion of clock component Arntl
A role for the adipocytes clock in the temporal organization of energy regulation is revealed, timing as a modulator of the adipocyte-hypothalamic axis is highlighted and the impact of timing of food intake on body weight is shown. Expand
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
It is concluded that measurements of MDA and isoprostanes in plasma and urine as well as 8-OHdG in urine are potential candidates for general biomarkers of oxidative stress. Expand
Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma.
15d-PGJ2 is detectable as a minor product of COX-2 in human urine, however, its biosynthesis is unaltered during or after COX activation in vivo by LPS, and is not the endogenous mediator of PPARgamma-dependent adipocyte activation and is un altered in clinical settings in which PPargamma activation has been implicated. Expand
Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles.
A novel mechanism of transcellular lipid metabolism whereby platelet activation may be amplified or modulated by concentrated delivery of arachidonic acid to adjacent platelets and endothelial cells is indicated. Expand
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function.
The results suggest that inhibitors of mPGES-1 may retain their antiinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences associated with PGHS-2-mediated PGI(2) suppression. Expand
Modulation of oxidant stress in vivo in chronic cigarette smokers.
Urinary 8-epi-PGF2 alpha may represent a noninvasive, quantitative index of oxidant stress in vivo and may be modulated by quitting cigarettes and switching to nicotine patches or by antioxidant vitamin therapy. Expand
Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
PGD2 is defined as an inhibitor of hair growth in AGA and the PGD2-GPR44 pathway is suggested as a potential target for treatment, providing new insight into the pathogenesis of AGA. Expand