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Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer
TLDR
This prospective study demonstrates accurate mutation detection in tumor tissues using ddPCR, and that ptDNA can be detected in blood before and after surgery in patients with early-stage breast cancer.
ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients
TLDR
A high frequency of ESR1 mutations is shown using circulating plasma tumor DNA (ptDNA) from patients with metastatic breast cancer and it is suggested that blood can be used to identify additional mutations not found by sequencing of a single metastatic lesion.
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
TLDR
It is shown that heterozygous BRCA1 inactivation results in genomic instability in nontumorigenic human breast epithelial cells in vitro and in vivo, and B RCA1 haploinsufficiency may accelerate hereditary breast carcinogenesis by facilitating additional genetic alterations.
Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.
TLDR
The nontumorigenic human breast epithelial cell line MCF-10A and hTERT-immortalized human mammary epithelial cells serves as a new model for elucidating the oncogenic contribution of mutant K-ras as expressed in a large fraction of human cancer cells.
PIK3CA and AKT1 Mutations Have Distinct Effects on Sensitivity to Targeted Pathway Inhibitors in an Isogenic Luminal Breast Cancer Model System
TLDR
AKT1 E17K is a bona fide oncogene in a human luminal breast cancer context and has implications for the use of tumor genome sequencing to assign patients to targeted therapies.
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.
TLDR
These results provide the first direct evidence that MMSET plays a significant role in t(4;14) MM and suggest that therapies targeting this gene could impact this particular subset of poor-prognosis patients.
The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
TLDR
Using this system, a mechanistic explanation for previous observations ascribing a dual role for AR signaling in human breast cancer cells is provided, providing an experimental system without the potential confounding effects of ERα/PR crosstalk.
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