Author pages are created from data sourced from our academic publisher partnerships and public sources.
Proangiogenic factor PlGF programs CD11b(+) myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors.
Tumor-mobilized bone marrow-derived CD11b(+) myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here, we show that… Expand
Inhibition of the Kit Ligand/c-Kit Axis Attenuates Metastasis in a Mouse Model Mimicking Local Breast Cancer Relapse after Radiotherapy
Purpose: Local breast cancer relapse after breast-saving surgery and radiotherapy is associated with increased risk of distant metastasis formation. The mechanisms involved remain largely elusive. We… Expand
T-cell activation by treatment of cancer patients with EMD 521873 (Selectikine), an IL-2/anti-DNA fusion protein
- J. Laurent, C. Touvrey, +13 authors D. Speiser
- Journal of Translational Medicine
- 7 January 2013
BackgroundEMD 521873 (Selectikine or NHS-IL2LT) is a fusion protein consisting of modified human IL-2 which binds specifically to the high-affinity IL-2 receptor, and an antibody specific for both… Expand
Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells.
- J. Laurent, C. Touvrey, F. Botta, F. Kuonen, C. Ruegg
- Biology, Medicine
- The International journal of developmental…
- 11 July 2011
Cancer-related inflammation has emerged in recent years as a major event contributing to tumor angiogenesis, tumor progression and metastasis formation. Bone marrow-derived and inflammatory cells… Expand
MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial
BackgroundImmunotherapy offers a promising novel approach for the treatment of cancer and both adoptive T-cell transfer and immune modulation lead to regression of advanced melanoma. However, the… Expand
Metabolic labeling and protein linearization technology allow the study of proteins secreted by cultured cells in serum-containing media.
- M. Colzani, P. Waridel, J. Laurent, E. Faes, C. Rüegg, M. Quadroni
- Medicine, Biology
- Journal of proteome research
- 27 August 2009
Supernatants from cell cultures (also called conditioned media, CMs) are commonly analyzed to study the pool of secreted proteins (secretome). To reduce the exogenous protein background, serum-free… Expand
Impact of 3 Different Short-term Chemotherapy Regimens on Lymphocyte-depletion and Reconstitution in Melanoma Patients
Recent immunotherapy trials have shown that lymphodepletion induced by short-term chemotherapy favors subsequent expansion of adoptively transferred T cells, by homeostatic mechanisms. To take… Expand
Angiogenic Activity of Breast Cancer Patients’ Monocytes Reverted by Combined Use of Systems Modeling and Experimental Approaches
- Nicolas Guex, I. Crespo, +18 authors Marie-Agnes Doucey
- Medicine, Computer Science
- PLoS Comput. Biol.
- 1 March 2015
Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor… Expand
An unusual case of metastatic melanoma sensitive to chemotherapy and immunotherapy, with late immune escape in the brain.
The incidence of skin melanoma is increasing worldwide with little or no improvement in mortality despite intensive research and treatment. Following the appearance of distant metastases overall… Expand
Sludge Minimization by Thermal Lysis during Biological Wastewater Treatment - Experimental Study, Model Set Up and Calibration
Sludge minimization by thermal treatment within activated sludge process was investigated at pilot scale. A 90°C treatment was set up in the return activated sludge loop. When keeping apparent sludge… Expand