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A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat.
In the present study rats were dosed from weaning, through puberty and gestation, to Day 15 of lactation with methoxychlor at 25, 50, 100, or 200 mg/kg/day. Morphological landmarks of puberty wereExpand
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A Dose-Response Analysis of Methoxychlor-Induced Alterations of Reproductive Development and Function in the Rat
In the present study rats were dosed from weaning, through puberty and gestation, to Day 15 of lactation with methoxychlor at 25, 50, 100, or 200 mg/kg/day. Morphological landmarks of puberty wereExpand
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Chronic manganese oxide administration to preweanling rats: manganese accumulation and distribution.
Mn accumulation was evaluated in selected tissues of preweanling rats dosed daily with particulate Mn3O4. Significant findings include a high rate of Mn accumulation in the preweanling rat; a MnExpand
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Cushing's syndrome associated with ectopic corticotropin production and small-cell lung cancer.
PURPOSE This study was undertaken to review the clinical and laboratory features and response to treatment of patients with Cushing's syndrome associated with ectopic corticotropinExpand
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The Metabolic Rate Constants and Specific Activity of Human and Rat Hepatic Cytochrome P-450 2E1 Toward Toluene and Chloroform
Chloroform (CHCl3) is a near-ubiquitous environmental contaminant, a by-product of the disinfection of drinking water sources and a commercially important compound. Standards for safe exposure haveExpand
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Effects of chronic manganese (Mn3O4) exposure on selected reproductive parameters in rats.
Long-Evans rats were chronically exposed to dietary Mn3O4 beginning on d 1 of gestation and continuing through 224 d of age. Dietary concentrations of Mn, as Mn3O4, were 350, 1050, and 3500 ppm andExpand
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Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats.
Testis function in fetal and peripubertal male rats is disrupted by subchronic exposure to phthalate esters (PEs). In contrast to the male rat, it is generally held that reproduction in female ratsExpand
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Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats.
The purpose of this study was to evaluate the effect(s) of acute in vivo cadmium (Cd) exposure on steroidogenesis in rat ovaries during different reproductive states. Sprague-Dawley rats wereExpand
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The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study
  • M. Hecker, H. Hollert, +12 authors G. Timm
  • Engineering, Environmental Science
  • Environmental science and pollution research…
  • 1 March 2011
Background, goals, and scopeIn response to increasing concerns regarding the potential of chemicals to interact with the endocrine system of humans and wildlife, various national and internationalExpand
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