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NO-mediated apoptosis in yeast
Results indicate that NO signalling and GAPDH S-nitrosation are linked with H2O2-induced apoptotic cell death, pointing to a physiological role of NO in yeast apoptosis. Expand
Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells.
The anti-inflammatory action of RWE, mechanistically supported by the modulation of cascades orchestrated by NF-κB and involving nitric oxide, suggests that RWE (a readily straightforward preparation when compared with the purification of specific compounds) may represent a simple and inexpensive therapeutic strategy in the context of intestinal inflammation. Expand
Two related phenolic antioxidants with opposite effects on vitamin E content in low density lipoproteins oxidized by ferrylmyoglobin: consumption vs regeneration.
Results suggest that caffeic acid acts synergistically with alpha-tocopherol, extending the antioxidant capacity of LDL by recycling alpha-ocopherol from thealpha-tocopheroxyl radical, and p-coumaric acid decreases the peroxidation chain rate. Expand
Red wine-dependent reduction of nitrite to nitric oxide in the stomach.
It is shown in vitro that wine, wine anthocyanin fraction and wine catechol (caffeic acid) dose- and pH-dependently promote the formation of *NO when mixed with nitrite, as measured electrochemically. Expand
Reactivity of dietary phenolic acids with peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation.
The interaction of four phenolic acids, representative of three chemical groups present in human diet, with peroxyl radicals was studied in vitro in a low density lipoprotein (LDL) oxidation model and the antioxidant activity of the various phenolic compounds is discussed in terms of structure-activity relationships. Expand
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium ofExpand
Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL
P phenolic acids (caffeic and ferulic acids being the most potent of the compounds tested under the conditions used) exhibit a potent cytoprotective effect of cultured endothelial cells against oxidized LDL. Expand
Nitric oxide signaling is disrupted in the yeast model for Batten disease.
It is proposed that in JNCL, a limited capacity to synthesize .NO directly caused by the absence of Cln3 function may contribute to the pathology of the disease. Expand
Redox Cycles of Caffeic Acid, alpha‐Tocopherol, and Ascorbate: Implications for Protection of Low‐Density Lipoproteins Against Oxidation
In independent experiments, the effects of caffeic acid and ascorbate on the oxidation of two low density lipoprotein (LDL) populations, control and alpha‐tocopherol enriched, were studied and results indicated thatalpha‐tocopheroxyl radical EPR signals acted synergistically to afford optimal protection of LDL against oxidation. Expand
Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation.
Novel molecular mechanisms by which luteolin may act against intestinal inflammation are uncovers, which might support the use of lutenolin as a future therapeutic strategy in IBD. Expand