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Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
- A. M. Shapiro, J. Lakey, +5 authors R. Rajotte
- The New England journal of medicine
- 27 July 2000
The observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass. Expand
Five-year follow-up after clinical islet transplantation.
In conclusion, islet transplantation can relieve glucose instability and problems with hypoglycemia and point to the need for further progress in the availability of transplantable islets, improving islet engraftment, preserving islet function, and reducing toxic immunosuppression. Expand
International trial of the Edmonton protocol for islet transplantation.
- A. Shapiro, C. Ricordi, +28 authors J. Lakey
- The New England journal of medicine
- 28 September 2006
Islet transplantation with the use of the Edmonton protocol can successfully restore long-term endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus and unstable control, but insulin independence is usually not sustainable. Expand
Hepatitis C virus replication in mice with chimeric human livers
These chimeric mice represent the first murine model suitable for studying the human hepatitis C virus in vivo and are considered to be a first-of-its-kind model. Expand
Successful islet transplantation: continued insulin reserve provides long-term glycemic control.
The results indicate that prolonged insulin independence can be achieved after islet transplantation, and there are some risks associated acutely with the procedure, and hypercholesterolemia and hypertension are treatable concerns on longer-term follow-up. Expand
Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol.
Islet transplantation has successfully corrected labile type 1 diabetes and problems with hypoglycemia, and the results show persistent insulin secretion, which is consistent with good glycemic control. Expand
Variables in organ donors that affect the recovery of human islets of Langerhans.
In an attempt to reduce the variability in the yields of human islet isolations and to identify donor factors that were potentially deleterious, retrospectively reviewed 153 human islets isolations in the center over a 3-year period suggests an improved approach to the prediction of successful islet isolation from human pancreases. Expand
Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.
T careful assessment of islet graft composition is needed in a clinical transplantation program to accurately estimate islet purity and assess the contribution of other cell types present, such as islet progenitor cells. Expand
Beta-score: an assessment of beta-cell function after islet transplantation.
The beta-score provides a simple clinical scoring system that encompasses glycemic control, diabetes therapy, and endogenous insulin secretion that correlates well with physiological measures of beta-cell function and is suitable as an overall measure ofbeta-cell transplant function. Expand
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Controlled perfusion via the pancreatic duct allows the effective delivery of the enzyme achieving maximal distension to all regions of the pancreas leading to an increased recovery of the islets with no detrimental effect on subsequent in vitro islet function. Expand