J. Lago

Publications279
h-index33
Citations4,553
Highly Influential Citations129
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Structure-Activity Association of Flavonoids in Lung Diseases
TLDR
The effects of different flavonoids in the control of lung inflammation in some disorders such as asthma, lung emphysema and acute respiratory distress syndrome are discussed and some structure-activity relationships between this biological potential and chemical profile of these compounds are established.
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Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update
TLDR
The potential use of these triterpenes against human pathogens, including their mechanisms of action, via in vivo studies, and the future perspectives about the use of compounds for human or even animal health are discussed.
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The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II.
TLDR
It is illustrated that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs.
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Chemical Composition and Cytotoxicity Evaluation of Essential Oil from Leaves of Casearia Sylvestris, Its Main Compound α-Zingiberene and Derivatives
TLDR
Results indicate that cytotoxic activity is related with the state of oxidation of compound.
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Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo.
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In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae).
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Essential oils from Schinus terebinthifolius leaves – chemical composition and in vitro cytotoxicity evaluation
TLDR
The obtained results indicated that the monoterpenes α- and β-pinenes could be responsible to the cytotoxic activity detected in the crude oil from leaves of S. terebinthifolius, and it was possibly inferred that the presence of double bond in their structures is crucial to cytotoxicity potential detected in these derivatives.
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Antiparasitic activity and effect of casearins isolated from Casearia sylvestris on Leishmania and Trypanosoma cruzi plasma membrane.
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α-Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model.
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Antifungal aromadendrane sesquiterpenoids from the leaves of Xylopia brasiliensis
TLDR
Os sesquiterpenos aromadendranos diidroxilados apresentaram atividade antifungica frente a Cladosporium cladosporioides, incluindo experimentos bidimensionais, alem de espectrometria de massas.
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