• Publications
  • Influence
α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models
Alpha-synuclein (αSyn) misfolding is associated with several devastating neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells and in neurons αSyn accumulation is cytotoxic,Expand
  • 1,140
  • 65
New functional activities for the p21 family of CDK inhibitors.
The association of cdk4 with D-type cyclins to form functional kinase complexes is comparatively inefficient. This has led to the suggestion that assembly might be a regulated step. In this report weExpand
  • 1,383
  • 61
High-resolution DNA-binding specificity analysis of yeast transcription factors.
Transcription factors (TFs) regulate the expression of genes through sequence-specific interactions with DNA-binding sites. However, despite recent progress in identifying in vivo TF binding sites byExpand
  • 390
  • 52
Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children
High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recentExpand
  • 475
  • 28
Self-Assembling Protein Microarrays
Protein microarrays provide a powerful tool for the study of protein function. However, they are not widely used, in part because of the challenges in producing proteins to spot on the arrays. WeExpand
  • 503
  • 18
Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells.
MCF10A mammary epithelial cells form growth-arrested structures when cultured in three-dimensional basement membrane gels. Activation of the receptor tyrosine kinase ErbB2 induces formation ofExpand
  • 231
  • 15
The sentinel within: exploiting the immune system for cancer biomarkers.
The release of proteins from tumors triggers an immune response in cancer patients. These tumor antigens arise from several mechanisms including tumor-specific alterations in protein expression,Expand
  • 258
  • 11
Proteome-scale purification of human proteins from bacteria
The completion of the human genome project and the development of high-throughput approaches herald a dramatic acceleration in the pace of biological research. One of the most compelling next stepsExpand
  • 250
  • 10
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
The availability of an annotated genome sequence for the yeast Saccharomyces cerevisiae has made possible the proteome-scale study of protein function and protein-protein interactions. These studiesExpand
  • 110
  • 8
Next generation high density self assembling functional protein arrays
We developed a high-density self-assembling protein microarray, based on the nucleic acid programmable protein array (NAPPA) concept, to display thousands of proteins that are produced and capturedExpand
  • 268
  • 7