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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
It is shown that metformin non-competitively inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase, resulting in an altered hepatocellular redox state, reduced conversion of lactate and glycerol to glucose, and decreased hepatic gluconeogenesis.
A chemical switch for inhibitor-sensitive alleles of any protein kinase
A chemical genetic strategy for sensitizing protein kinases to cell-permeable molecules that do not inhibit wild-type kinases is described, allowing for rapid functional characterization of members of this important gene family.
Identifying the proteins to which small-molecule probes and drugs bind in cells
- S. Ong, M. Schenone, S. Carr
- Biology, ChemistryProceedings of the National Academy of Sciences
- 24 March 2009
A powerful method combining quantitative proteomics (SILAC) with affinity enrichment is described to provide unbiased, robust and comprehensive identification of the proteins that bind to small-molecule probes and drugs.
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
- C. Polycarpo, A. Ambrogelly, D. Söll
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 24 August 2004
In vitro data suggest that Methanosarcina cells have two pathways for acylating the suppressor tRNA(Pyl), which would ensure efficient translation of the in-frame UAG codon in case of pyrrolysine deficiency and safeguard the biosynthesis of the proteins whose genes contain this special codon.
Pyrrolysine analogues as substrates for pyrrolysyl‐tRNA synthetase
Detoxication of cyanide by cystine.
The cystathionase-rhodanese system.
The metabolism of thiocyanate in the rat and its inhibition by propylthiouracil.
Labeled sulfur uptake by thyroids of rats with low plasma thiocyanate levels.
Increasing the kinase specificity of k252a by protein surface recognition.
- T. L. Schneider, R. Mathew, K. P. Rice, K. Tamaki, J. L. Wood, A. Schepartz
- BiologyOrganic letters
- 2 April 2005
Miniature protein 1 recognizes PKA with an affinity that rivals that of PKI and, in the context of 1-K252a, leads to a dramatic increase in kinase specificity.