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A chemical switch for inhibitor-sensitive alleles of any protein kinase
Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts toExpand
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion,Expand
Identifying the proteins to which small-molecule probes and drugs bind in cells
Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more proteins. A complete understanding of the interacting proteins and their associated protein complexes, whetherExpand
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
Pyrrolysine, the 22nd cotranslationally inserted amino acid, was found in the Methanosarcina barkeri monomethylamine methyltransferase protein in a position that is encoded by an in-frame UAG stopExpand
Autoregulation of Cell-specific MAP Kinase Control of the Tryptophan Hydroxylase Promoter*
The neurotransmitter serotonin controls a wide range of biological systems, including its own synthesis and release. As the rate-limiting enzyme in serotonin biosynthesis, tryptophan hydroxylaseExpand
Detoxication of cyanide by cystine.
SUMMARY Chemical studies on the nature of the reaction product between cystine and cyanide ion support formulation of the structure as 2-imino-4-thiazoli- dinecarboxylic acid. The compound was inertExpand
The cystathionase-rhodanese system.
Abstract Cystathionase ( l -homoserine hydrolase (deaminating), EC and rhodanese ∗∗ (thiosulfate: cyanide sulfurtransferase, EC have been combined to form a coupled enzyme systemExpand
The metabolism of thiocyanate in the rat and its inhibition by propylthiouracil.
In a previous report (1) we have shown that a small fraction of the sulfur of injected thiocyanate is converted to sulfate by the rat. The conversion of thiocyanate to sulfate had been predicted toExpand
Pyrrolysine analogues as substrates for pyrrolysyl‐tRNA synthetase
In certain methanogenic archaea a new amino acid, pyrrolysine (Pyl), is inserted at in‐frame UAG codons in the mRNAs of some methyltransferases. Pyl is directly acylated onto a suppressor tRNAPyl byExpand
Labeled sulfur uptake by thyroids of rats with low plasma thiocyanate levels.
In a previous paper (1) we reported data, based upon the use of radiosulfur, showing that in the rat the affinity of the whole thyroid for thiocyanate ion is slight but is significantly greater thanExpand