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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
TLDR
It is shown that metformin non-competitively inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase, resulting in an altered hepatocellular redox state, reduced conversion of lactate and glycerol to glucose, and decreased hepatic gluconeogenesis.
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A chemical switch for inhibitor-sensitive alleles of any protein kinase
TLDR
A chemical genetic strategy for sensitizing protein kinases to cell-permeable molecules that do not inhibit wild-type kinases is described, allowing for rapid functional characterization of members of this important gene family.
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Identifying the proteins to which small-molecule probes and drugs bind in cells
TLDR
A powerful method combining quantitative proteomics (SILAC) with affinity enrichment is described to provide unbiased, robust and comprehensive identification of the proteins that bind to small-molecule probes and drugs.
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An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
TLDR
In vitro data suggest that Methanosarcina cells have two pathways for acylating the suppressor tRNA(Pyl), which would ensure efficient translation of the in-frame UAG codon in case of pyrrolysine deficiency and safeguard the biosynthesis of the proteins whose genes contain this special codon.
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Pyrrolysine analogues as substrates for pyrrolysyl‐tRNA synthetase
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Detoxication of cyanide by cystine.
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The cystathionase-rhodanese system.
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The metabolism of thiocyanate in the rat and its inhibition by propylthiouracil.
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Labeled sulfur uptake by thyroids of rats with low plasma thiocyanate levels.
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Increasing the kinase specificity of k252a by protein surface recognition.
TLDR
Miniature protein 1 recognizes PKA with an affinity that rivals that of PKI and, in the context of 1-K252a, leads to a dramatic increase in kinase specificity.
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