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The effects of interferon-alpha on the production and action of other cytokines.
Various interferon-alpha (IFN-alpha) preparations, either as individual subtypes or natural mixtures, induce or inhibit expression of several other cytokines, as well as cytokine receptors andExpand
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Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors.
Capsaicinoids, found in less-than-lethal self-defense weapons, have been associated with respiratory failure and death in exposed animals and people. The studies described herein provide evidence forExpand
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Slowly changing bioelectric potentials associated with the blood-brain barrier.
A slowly changing bioelectric potential difference (P.D.) is measured in rats, rabbits, cats and dogs between various regions of the central nervous system (CNS) and the blood within the jugular ve...
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A novel bioassay for the determination of neutralizing antibodies to IFN-beta1b.
We have adapted the new MxA gene-induction bioassay to measure neutralizing antibodies to interferon-beta1b (IFN-beta1b, the active ingredient in Betaseron) in sera from patients treated withExpand
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Effect of temperature on the seasonal production of testicular androgens, in vitro, by the lizard Tiliqua rugosa.
The effect of temperature on the seasonal production of testicular androgens, in vitro, was examined in the scincid lizard Tiliqua (Trachydosaurus) rugosa. Testicular tissue was incubated, in vitro,Expand
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Recent progress in interferon research: molecular mechanisms of regulation, action, and virus circumvention.
A complex system of cis regulatory elements exists by which induction of IFN gene expression is initiated in response to a variety of inducers; cis elements also appear to be involved in theExpand
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Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease.
Intravenous (i.v.) injection of u.v. light-inactivated herpes simplex virus type 1 (UV HSV-1) at the time of HSV-1 corneal infection reduced the cytotoxic T lymphocyte (CTL) response to HSV-1, andExpand
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Annual cycles of plasma and testicular androgens in the lizard Tiliqua (Trachydosaurus) rugosa.
Androgen production during the annual reproductive cycle was investigated in the male scincid lizard Tiliqua (Trachydosaurus) rugosa. Concentrations of testosterone and epitestosterone were measuredExpand
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Identification of epitestosterone in the plasma and testis of the lizard Tiliqua (Trachydosaurus) rugosa.
Blood and testicular extracts of the scincid lizard Tiliqua (Trachydosaurus) rugosa were analyzed using thin-layer, column, and high-performance liquid chromatography. The major androgens isolatedExpand
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Synergistic antiherpes virus activity of acyclovir and interferon in human corneal stromal cells.
Synergistic anti-herpes simplex virus type 1 (HSV-1) activity between acyclovir (ACV) and recombinant human interferon alpha A2 (IFN) was detected in cell cultures derived from human corneas. ThisExpand
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